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Risk of metabolic d...
Risk of metabolic disorders in childless men : A population-based cohort study
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- Bungum, Ane Berger (författare)
- Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups,Bispebjerg Hospital
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- Glazer, Clara Helene (författare)
- Bispebjerg Hospital
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- Bonde, Jens Peter (författare)
- Bispebjerg Hospital
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- Nilsson, Peter M. (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital
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- Giwercman, Aleksander (författare)
- Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups
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- Tøttenborg, Sandra Søgaard (författare)
- Bispebjerg Hospital
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(creator_code:org_t)
- 2018-08-17
- 2018
- Engelska.
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Ingår i: BMJ Open. - : BMJ. - 2044-6055. ; 8:8
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://bmjopen.bmj....
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective To study whether male childlessness is associated with an increased risk of metabolic disorders such as metabolic syndrome (MetS) and diabetes. Design A population-based cohort study. Setting Not applicable. Participants 2572 men from the population-based Malmö Diet and Cancer Cardiovascular Cohort. Interventions None. Main outcome measures From cross-sectional analyses, main outcome measures were ORs and 95% CIs for MetS and diabetes among childless men. In prospective analyses, HRs and 95% CI for diabetes among childless men. Results At baseline, in men with a mean age of 57 years, the prevalence of MetS was 26% and 22% among childless men and fathers, respectively. Similarly, we observed a higher prevalence of diabetes of 11% among childless men compared with 5% among fathers. In the cross-sectional adjusted analyses, childless men had a higher risk of MetS and diabetes, with ORs of 1.22 (95% CI 0.87 to 1.72) and 2.12 (95% CI 1.34 to 3.36) compared with fathers. In the prospective analysis, during a mean follow-up of 18.3 years, we did not see any increase in diabetes risk among childless men (HR 1.02 (0.76 to 1.37)). Conclusion This study provides evidence of an association between male childlessness and a higher risk of MetS and diabetes. However, as these associations were found in cross-sectional analyses, reverse causation cannot be excluded.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- childlessness
- diabetes
- infertility
- metabolic syndrome
- register-based cohort study
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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