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  • Loring, ZakDuke Clinical Research Institute (DCRI),Duke University (author)

Acute echocardiographic and hemodynamic response to his-bundle pacing in patients with first-degree atrioventricular block

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-04-21
  • Wiley,2022

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:08f58af7-908b-4568-9936-1c9b585c7e10
  • https://lup.lub.lu.se/record/08f58af7-908b-4568-9936-1c9b585c7e10URI
  • https://doi.org/10.1111/anec.12954DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background: Atrial pacing and right ventricular (RV) pacing are both associated with adverse outcomes among patients with first-degree atrioventricular block (1°AVB). His-bundle pacing (HBP) provides physiological activation of the ventricle and may be able to improve both atrioventricular (AV) and inter-ventricular synchrony in 1°AVB patients. This study evaluates the acute echocardiographic and hemodynamic effects of atrial, atrial-His-bundle sequential (AH), and atrial-ventricular (AV) sequential pacing in 1°AVB patients. Methods: Patients with 1°AVB undergoing atrial fibrillation ablation were included. Following left atrial (LA) catheterization, patients underwent atrial, AH- and AV-sequential pacing. LA/left ventricular (LV) pressure and echocardiographic measurements during the pacing protocols were compared. Results: Thirteen patients with 1°AVB (mean PR 221 ± 26 ms) were included. The PR interval was prolonged with atrial pacing compared to baseline (275 ± 73 ms, p =.005). LV ejection fraction (LVEF) was highest during atrial pacing (62 ± 11%), intermediate with AH-sequential pacing (59 ± 7%), and lowest with AV-sequential pacing (57 ± 12%) though these differences were not statistically significant. No significant differences were found in LA or LV mean pressures or LV dP/dT. LA and LV volumes, isovolumetric times, electromechanical delays, and global longitudinal strains were similar across pacing protocols. Conclusion: Despite pronounced PR prolongation, the acute effects of atrial pacing were not significantly different than AH- or AV-sequential pacing. Normalizing atrioventricular and/or inter-ventricular dyssynchrony did not result in acute improvements in cardiac output or loading conditions.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Holmqvist, FredrikLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Electrocardiology Research Group - CIEL,Forskargrupper vid Lunds universitet,Clinical studies af Atrial Fibrillation,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Duke University(Swepub:lu)kard-fho (author)
  • Sze, EdwardDuke University,Maine Medical Center (author)
  • Alenezi, FawazDuke University (author)
  • Campbell, KristenDuke University Medical Center,Maine Medical Center (author)
  • Koontz, Jason I.Duke University (author)
  • Velazquez, Eric J.Yale University,Duke University (author)
  • Atwater, Brett D.Duke University,Inova Heart and Vascular Institute (author)
  • Bahnson, Tristram D.Duke University (author)
  • Daubert, James P.Duke University (author)
  • Duke Clinical Research Institute (DCRI)Duke University (creator_code:org_t)

Related titles

  • In:Annals of Noninvasive Electrocardiology: Wiley27:41082-720X1542-474X

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