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Imaging Markers of ...
Imaging Markers of Brain Frailty and Outcome in Patients With Acute Ischemic Stroke
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- Bu, Ning (författare)
- Second Affiliated Hospital of Xi'an Jiaotong University
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- Khlif, Mohamed Salah (författare)
- The Florey Institute of Neuroscience and Mental Health
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- Lemmens, Robin (författare)
- Catholic University of Leuven,University Hospitals Leuven
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- Wouters, Anke (författare)
- University Hospitals Leuven,Catholic University of Leuven
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- Fiebach, Jochen B. (författare)
- Charité - University Medicine Berlin
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- Chamorro, Angel (författare)
- University of Barcelona
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- Ringelstein, E. Bernd (författare)
- University of Münster
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- Norrving, Bo (författare)
- Lund University,Lunds universitet,Stroke policy och kvalitetsregisterforskning,Forskargrupper vid Lunds universitet,Stroke policy and quality register research,Lund University Research Groups
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- Laage, Rico (författare)
- Guided Development GmbH
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- Grond, Martin (författare)
- Kreisklinikum Siegen,Philipp University of Marburg
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- Wilms, Guido (författare)
- University Hospitals Leuven
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- Brodtmann, Amy (författare)
- The Florey Institute of Neuroscience and Mental Health
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- Thijs, Vincent (författare)
- The Florey Institute of Neuroscience and Mental Health
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(creator_code:org_t)
- 2021
- 2021
- Engelska 8 s.
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Ingår i: Stroke. - 1524-4628. ; 52:3, s. 1004-1011
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND AND PURPOSE: Functional outcome after stroke may be related to preexisting brain health. Several imaging markers of brain frailty have been described including brain atrophy and markers of small vessel disease. We investigated the association of these imaging markers with functional outcome after acute ischemic stroke. METHODS: We retrospectively studied patients with acute ischemic stroke enrolled in the AXIS-2 trial (AX200 in Ischemic Stroke Trial), a randomized controlled clinical trial of granulocyte colony-stimulating factor versus placebo. We assessed the ratio of brain parenchymal volume to total intracerebral volumes (ie, the brain parenchymal fraction) and total brain volumes from routine baseline magnetic resonance imaging data obtained within 9 hours of symptom onset using the unified segmentation algorithm in SPM12. Enlarged perivascular spaces, white matter hyperintensities, lacunes, as well as a small vessel disease burden, were rated visually. Functional outcomes (modified Rankin Scale score) at day 90 were determined. Logistic regression was used to test associations between brain imaging features and functional outcomes. RESULTS: We enrolled 259 patients with a mean age of 69±12 years and 46 % were female. Increased brain parenchymal fraction was associated with higher odds of excellent outcome (odds ratio per percent increase, 1.078 [95% CI, 1.008-1.153]). Total brain volumes and small vessel disease burden were not associated with functional outcome. An interaction between brain parenchymal fraction and large vessel occlusion on excellent outcome was not observed. CONCLUSIONS: Global brain health, as assessed by brain parenchymal fraction on magnetic resonance imaging, is associated with excellent functional outcome after ischemic stroke. Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT00927836.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- atrophy
- frailty
- granulocyte colony
- magnetic resonance imaging
- stimulating factor
- white matter
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Stroke
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- Av författaren/redakt...
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Bu, Ning
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Khlif, Mohamed S ...
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Lemmens, Robin
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Wouters, Anke
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Fiebach, Jochen ...
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Chamorro, Angel
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visa fler...
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Ringelstein, E. ...
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Norrving, Bo
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Laage, Rico
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Grond, Martin
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Wilms, Guido
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Brodtmann, Amy
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Thijs, Vincent
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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Stroke
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Lunds universitet