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Differentiation of ...
Differentiation of the Gastric Mucosa I. Role of histamine in control of function and integrity of oxyntic mucosa: understanding gastric physiology through disruption of targeted genes
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Chen, Duan (author)
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Aihara, Takeshi (author)
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Zhao, Chun-Mei (author)
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- Håkanson, Rolf (author)
- Lund University,Lunds universitet,Drug Target Discovery,Forskargrupper vid Lunds universitet,Lund University Research Groups
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Okabe, Susumu (author)
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(creator_code:org_t)
- American Physiological Society, 2006
- 2006
- English.
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In: American Journal of Physiology: Gastrointestinal and Liver Physiology. - : American Physiological Society. - 1522-1547 .- 0193-1857. ; 291:4, s. 539-544
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Many physiological functions of the stomach depend on an intact mucosal integrity; function reflects structure and vice versa. Histamine in the stomach is synthesized by histidine decarboxylase (HDC), stored in enterochromaffin-like (ECL) cells, and released in response to gastrin, acting on CCK2 receptors on the ECL cells. Mobilized ECL cell histamine stimulates histamine H-2 receptors on the parietal cells, resulting in acid secretion. The parietal cells express H-2, M-3, and CCK2 receptors and somatostatin sst(2) receptors. This review discusses the consequences of disrupting genes that are important for ECL cell histamine release and synthesis (HDC, gastrin, and CCK2 receptor genes) and genes that are important for "cross-talk" between H-2 receptors and other receptors on the parietal cell (CCK2, M-3, and sst(2) receptors). Such analysis may provide insight into the functional significance of gastric histamine.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- gastric acid secretion
- knockout mice
- oxyntic mucosal proliferation
- gastrin
- and differentiation
- gastrin receptor
- histamine
Publication and Content Type
- art (subject category)
- ref (subject category)
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