Exposure to PCB and p,p '-DDE in European and Inuit populations: impact on human sperm chromatin integrity

BACKGROUND: Persistent organochlorine pollutants ( POP), such as polychlorinated biphenyls (PCB) and dichlorodiphenyldichloroethylene (p,p'-DDE), are widely found in the environment and considered potential endocrine-disrupting compounds (EDC). Their impact on male fertility is still unknown. METHODS: To explore the hypothesis that POP is associated with altered sperm chromatin integrity, a cross-sectional study involving 707 adult males ( 193 Inuits from Greenland, 178 Swedish fishermen, 141 men from Warsaw, Poland, and 195 men from Kharkiv, Ukraine) was carried out. Serum levels of 2,2', 4,4', 5,5'-hexachlorobiphenyl (CB-153), as a proxy of the total PCB burden, and of p,p'-DDE were determined. Sperm chromatin structure assay (SCSA) was used to assess sperm DNA/chromatin integrity. RESULTS: We found a strong and monotonically increasing DNA fragmentation index with increasing serum levels of CB-153 among European but not Inuit men, reaching a 60% higher average level in the highest exposure group. No significant associations were found between SCSA-derived parameters and p,p'-DDE serum concentrations. CONCLUSION: These results suggest that human dietary PCB exposure might have a negative impact on the sperm chromatin integrity of adult males but additional issues, including differences in the genetic background and lifestyle habits, still need to be elucidated.

Toft, G (författare)
Hagmar, L (författare)
Eleuteri, P (författare)
Rescia, M (författare)
Rignell-Hydbom, AnnaLund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)ymed-arh (författare)
Tyrkiel, E (författare)
Zvyezday, V (författare)
Bonde, JP (författare)
Avdelningen för arbets- och miljömedicinInstitutionen för laboratoriemedicin (creator_code:org_t)

Ingår i:Human Reproduction: Oxford University Press (OUP)20:12, s. 3488-34990268-11611460-2350

Av författaren/redakt...: Spano, M; Toft, G; Hagmar, L; Eleuteri, P; Rescia, M; Rignell-Hydbom, ...; visa fler...; Tyrkiel, E; Zvyezday, V; Bonde, JP; visa färre...

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