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Molecular profiles ...
Molecular profiles of small cell lung cancer subtypes : therapeutic implications
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- Schwendenwein, Anna (författare)
- Medical University of Vienna
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- Megyesfalvi, Zsolt (författare)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary,National Institute of Oncology, Budapest,Medical University of Vienna,Semmelweis University
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- Barany, Nandor (författare)
- Medical University of Vienna,National Korányi Institute for Tuberculosis and Pulmonology, Hungary,Semmelweis University
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- Valko, Zsuzsanna (författare)
- Medical University of Vienna,National Korányi Institute for Tuberculosis and Pulmonology, Hungary
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- Bugyik, Edina (författare)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary
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- Lang, Christian (författare)
- Medical University of Vienna
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- Ferencz, Bence (författare)
- National Institute of Oncology, Budapest,Semmelweis University,National Korányi Institute for Tuberculosis and Pulmonology, Hungary
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- Paku, Sandor (författare)
- Semmelweis University
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- Lantos, Andras (författare)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary
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- Fillinger, Janos (författare)
- National Institute of Oncology, Budapest,National Korányi Institute for Tuberculosis and Pulmonology, Hungary,Semmelweis University
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- Rezeli, Melinda (författare)
- Lund University,Lunds universitet,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Clinical Protein Science and Imaging,Forskargrupper vid Lunds universitet,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Lund University Research Groups
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- Marko-Varga, Gyorgy (författare)
- Lund University,Lunds universitet,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Clinical Protein Science and Imaging,Forskargrupper vid Lunds universitet,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Lund University Research Groups
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- Bogos, Krisztina (författare)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary
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- Galffy, Gabriella (författare)
- Torokbalint County Institute of Pulmonology
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- Renyi-Vamos, Ferenc (författare)
- National Institute of Oncology, Budapest,Semmelweis University,National Korányi Institute for Tuberculosis and Pulmonology, Hungary
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- Hoda, Mir Alireza (författare)
- Medical University of Vienna
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- Klepetko, Walter (författare)
- Medical University of Vienna
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- Hoetzenecker, Konrad (författare)
- Medical University of Vienna
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- Laszlo, Viktoria (författare)
- National Institute of Oncology, Budapest,National Korányi Institute for Tuberculosis and Pulmonology, Hungary,Medical University of Vienna,Semmelweis University
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- Dome, Balazs (författare)
- Semmelweis University,Medical University of Vienna,National Institute of Oncology, Budapest,National Korányi Institute for Tuberculosis and Pulmonology, Hungary
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- Engelska 14 s.
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Ingår i: Molecular Therapy - Oncolytics. - : Elsevier BV. - 2372-7705. ; 20, s. 470-483
- Relaterad länk:
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http://dx.doi.org/10... (free)
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http://www.cell.com/...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Small cell lung cancer (SCLC; accounting for approximately 13%–15% of all lung cancers) is an exceptionally lethal malignancy characterized by rapid doubling time and high propensity to metastasize. In contrast to the increasingly personalized therapies in other types of lung cancer, SCLC is still regarded as a homogeneous disease and the prognosis of SCLC patients remains poor. Recently, however, substantial progress has been made in our understanding of SCLC biology. Advances in genomics and development of new preclinical models have facilitated insights into the intratumoral heterogeneity and specific genetic alterations of this disease. This worldwide resurgence of studies on SCLC has ultimately led to the development of novel subtype-specific classifications primarily based on the neuroendocrine features and distinct molecular profiles of SCLC. Importantly, these biologically distinct subtypes might define unique therapeutic vulnerabilities. Herein, we summarize the current knowledge on the molecular profiles of SCLC subtypes with a focus on their potential clinical implications. Small cell lung cancer is still regarded as a homogeneous disease associated with poor prognosis. Recent analysis, however, has led to the development of novel subtype-specific classifications primarily based on the neuroendocrine features and molecular profiles. The better understanding of these biologically distinct subtypes might help to define unique therapeutic vulnerabilities.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- heterogeneity
- molecular profile
- neuroendocrine
- small cell lung cancer
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Schwendenwein, A ...
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Megyesfalvi, Zso ...
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Barany, Nandor
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Valko, Zsuzsanna
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Bugyik, Edina
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Lang, Christian
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visa fler...
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Ferencz, Bence
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Paku, Sandor
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Lantos, Andras
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Fillinger, Janos
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Rezeli, Melinda
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Marko-Varga, Gyo ...
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Bogos, Krisztina
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Galffy, Gabriell ...
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Renyi-Vamos, Fer ...
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Hoda, Mir Alirez ...
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Klepetko, Walter
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Hoetzenecker, Ko ...
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Laszlo, Viktoria
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Dome, Balazs
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