Search: id:"swepub:oai:lup.lub.lu.se:0bca347f-58e4-4e46-9572-33049ee18a16" >
Relative risks of c...
-
Yuen, Kevin C.J.Swedish Medical Center
(author)
Relative risks of contributing factors to morbidity and mortality in adults with craniopharyngioma on growth hormone replacement
- Article/chapterEnglish2018
Publisher, publication year, extent ...
-
2017-09-29
-
The Endocrine Society,2018
-
10 s.
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:0bca347f-58e4-4e46-9572-33049ee18a16
-
https://lup.lub.lu.se/record/0bca347f-58e4-4e46-9572-33049ee18a16URI
-
https://doi.org/10.1210/jc.2017-01542DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
Context: In adults, craniopharyngioma (CP) of either childhood-onset (CO-CP) or adult-onset (AOCP) is associated with increased morbidity and mortality, but data on the relative risks (RRs) of contributing factors are lacking. Objective: To assess the RRs of factors contributing to morbidity and mortality in adults with CO-CP and AO-CP. Methods: Data on 1669 patients with CP from KIMS (Pfizer International Metabolic Database) were analyzed using univariate and multiple Poisson and Cox regression methods. Results:WhenCO-CP andAO-CP groupswere combined, history of stroke and hyperlipidemia increased cardiovascular risk, higher bodymass index (BMI) and radiotherapy increased cerebrovascular risk, and increased waist circumference increased the risk of developing diabetes mellitus (DM). Comparedwith patients with CO-CP, patients with AO-CP had a threefold higher risk of tumor recurrence, whereas being female and previous radiotherapy exposure conferred lower risks. Radiotherapy and older age with every 10 years from disease onset conferred a 2.3-To 3.5-fold risk for developing new intracranial tumors, whereas older age, greater and/or increasing BMI, history of stroke, and lower insulinlike growth factor I (IGF-I) standard deviation scoremeasured at last sampling before death were related to increased all-cause mortality. Compared with the general population, adults with CP had 9.3-, 8.1-, and 2.2-fold risks of developing DM, new intracranial tumors, and early death, respectively. Conclusion: Conventional factors that increase the risks of cardio-And cerebrovascular diseases and DM and risks for developing new intracranial tumors contributed to excess morbidity and mortality. In addition, lower serum IGF-I level measured from the last sample before death was inversely associated with mortality risk in patients with CP.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Mattsson, Anders F.Pfizer Inc. US
(author)
-
Burman, PiaLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-bap
(author)
-
Erfurth, Eva MarieSkåne University Hospital(Swepub:lu)med-ee0
(author)
-
Camacho-Hubner, CeciliaPfizer Inc. US
(author)
-
Fox, Janet L.Pfizer Inc. US
(author)
-
Verhelst, Johan
(author)
-
Geffner, Mitchell E.University of Southern California
(author)
-
Abs, RogerNo affiliation available (private)
(author)
-
Swedish Medical CenterPfizer Inc. US
(creator_code:org_t)
Related titles
-
In:Journal of Clinical Endocrinology and Metabolism: The Endocrine Society103:2, s. 768-7770021-972X1945-7197
Internet link
Find in a library
To the university's database