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Quantitative proteo...
Quantitative proteomics reveals specific metabolic features of Acute Myeloid Leukemia stem cells
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- Raffel, Simon (author)
- Heidelberg University
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- Klimmeck, Daniel (author)
- German Cancer Research Centre
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Falcone, Mattia (author)
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Demir, Aykut (author)
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Pouya, Alireza (author)
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Zeisberger, Petra (author)
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Lutz, Cristoph (author)
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- Tinelli, Marco (author)
- Sinsheim Hospital
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Bischel, Oliver (author)
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- Bullinger, Lars (author)
- Charité - University Medicine Berlin
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Thiede, Christian (author)
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Flörcken, Anne (author)
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Ehninger, Gerhard (author)
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- Ho, Anthony (author)
- University Hospital Heidelberg
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Müller-Tidow, Carsten (author)
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Gu, Zuguang (author)
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Hermann, Carl (author)
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Krijgsveld, Jeroen (author)
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Trumpp, Andreas (author)
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- Hansson, Jenny (author)
- Lund University,Lunds universitet,Avdelningen för molekylär hematologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Proteomisk hematologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Molecular Hematology (DMH),Department of Laboratory Medicine,Faculty of Medicine,Proteomic Hematology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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(creator_code:org_t)
- American Society of Hematology, 2020
- 2020
- English 13 s.
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In: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 136:13, s. 1507-1519
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http://dx.doi.org/10...
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Abstract
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- Acute myeloid leukemia is characterized by the accumulation of clonal myeloid blast cells unable to differentiate into mature leukocytes. Chemotherapy induces remission in the majority of patients, but relapse rates are high and lead to poor clinical outcomes. Because this is primarily caused by chemotherapy-resistant leukemic stem cells (LSCs), it is essential to eradicate LSCs to improve patient survival. LSCs have predominantly been studied at the transcript level, thus information about posttranscriptionally regulated genes and associated networks is lacking. Here, we extend our previous report on LSC proteomes to healthy age-matched hematopoietic stem and progenitor cells (HSPCs) and correlate the proteomes to the corresponding transcriptomes. By comparing LSCs to leukemic blasts and healthy HSPCs, we validate candidate LSC markers and highlight novel and potentially targetable proteins that are absent or only lowly expressed in HSPCs. In addition, our data provide strong evidence that LSCs harbor a characteristic energy metabolism, adhesion molecule composition, as well as RNA-processing properties. Furthermore, correlating proteome and transcript data of the same individual samples highlights the strength of proteome analyses, which are particularly potent in detecting alterations in metabolic pathways. In summary, our study provides a comprehensive proteomic and transcriptomic characterization of functionally validated LSCs, blasts, and healthy HSPCs, representing a valuable resource helping to design LSC-directed therapies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- art (subject category)
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Blood
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- By the author/editor
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Raffel, Simon
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Klimmeck, Daniel
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Falcone, Mattia
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Demir, Aykut
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Pouya, Alireza
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Zeisberger, Petr ...
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show more...
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Lutz, Cristoph
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Tinelli, Marco
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Bischel, Oliver
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Bullinger, Lars
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Thiede, Christia ...
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Flörcken, Anne
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Ehninger, Gerhar ...
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Ho, Anthony
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Müller-Tidow, Ca ...
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Gu, Zuguang
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Hermann, Carl
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Krijgsveld, Jero ...
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Trumpp, Andreas
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Hansson, Jenny
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Blood
- By the university
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Lund University