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Impact of tuberculo...
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Gomes, Victor F.
(författare)
Impact of tuberculosis exposure at home on mortality in children under 5 years of age in Guinea-Bissau
- Artikel/kapitelEngelska2011
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LIBRIS-ID:oai:lup.lub.lu.se:0d22c7aa-19d0-49fc-9153-e79caa0a62b1
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https://lup.lub.lu.se/record/1876870URI
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https://doi.org/10.1136/thx.2010.141309DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Objective To assess mortality related to exposure to tuberculosis (TB) at home among children in urban areas of Guinea-Bissau. Methods In four suburban areas included in the demographic surveillance system of the Bandim Health Project in Bissau, the mortality of children aged <5 years living with an adult with TB was compared with the mortality of children in the general population. Results Children <5 years of age exposed to an adult with intrathoracic TB had 66% higher mortality than unexposed children (HR 1.66, 95% CI 1.2 to 2.3). The risk was higher for children living in the same family as a TB case (HR 2.15, 95% CI 1.3 to 3.7) than for children living in the same house but not belonging to the same family as the TB case (HR 1.51, 95% CI 1.0 to 2.2). For children whose mother had TB, mortality was increased eightfold (HR 7.82, 95% CI 2.1 to 30). The risk of death was particularly increased from 6 months following exposure (HR 2.16, 95% CI 1.5 to 3.2) and the highest rate of excess mortality was found in children aged 3-4 years. Excess mortality was highest among children with close contact with an adult with sputum-positive pulmonary TB (HR 1.90, 95% CI 1.1 to 3.2), but contact with a sputum-negative case was also associated with increased mortality (HR 1.55, 95% CI 1.0 to 2.3). Adjusting for potential confounding factors did not change these results. The mortality among children living in the same houses 3 years earlier was not increased (HR 0.90, 95% CI 0.6 to 1.3). Conclusion Intimate family contact with a TB case represents a significant risk factor for child mortality in a low-income country.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Andersen, Andreas
(författare)
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Wejse, Christian
(författare)
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Oliveira, Ines
(författare)
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Vieira, Fina J.
(författare)
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Joaquim, Luis Carlos
(författare)
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Vieira, Cesaltina S.
(författare)
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Aaby, Peter
(författare)
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Gustafson, PerLund University,Lunds universitet,Enheten för infektionssjukdomar,Forskargrupper vid Lunds universitet,Infectious Diseases Research Unit,Lund University Research Groups(Swepub:lu)inf-pgu
(författare)
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Enheten för infektionssjukdomarForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Thorax: BMJ66:2, s. 163-1671468-32960040-6376
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