Effect of polyamine deficiency on proteins involved in Okazaki fragment maturation.

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Johansson, VeronicaLund University,Lunds universitet,Biologiska institutionen,Naturvetenskapliga fakulteten,Department of Biology,Faculty of Science (author)

Effect of polyamine deficiency on proteins involved in Okazaki fragment maturation.

Article/chapterEnglish2008

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2013-01-02
Wiley,2008

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LIBRIS-ID:oai:lup.lub.lu.se:0daf9ffa-f3ad-4d3b-a803-9e10fb76def5
https://lup.lub.lu.se/record/1243097URI
https://doi.org/10.1016/j.cellbi.2008.08.018DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

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Polyamine depletion causes S phase prolongation, and earlier studies indicate that the elongation step of DNA replication is affected. This led us to investigate the effects of polyamine depletion on enzymes crucial for Okazaki fragment maturation in the two breast cancer cell lines MCF-7 and L56Br-C1. In MCF-7 cells, treatment with N(1),N(11)-diethylnorspermine (DENSPM) causes S phase prolongation. In L56Br-C1 cells the prolongation is followed by massive apoptosis. In the present study we show that L56Br-C1 cells have substantially lower basal expressions of two Okazaki fragment maturation key proteins, DNA ligase I and FEN1, than MCF-7 cells. Thus, these two proteins might be promising markers for prediction of polyamine depletion sensitivity, something that can be useful for cancer treatment with polyamine analogues. DENSPM treatment affects the cellular distribution of FEN1 in L56Br-C1 cells, but not in MCF-7 cells, implying that FEN1 is affected by or involved in DENSPM-induced apoptosis.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
CGP 48664
DENSPM
human breast cancer
FEN1
DNA ligase I

Added entries (persons, corporate bodies, meetings, titles ...)

Falck Miniotis, Maria (author)
Hegardt, CeciliaLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)zoof-che (author)
Jönsson, Göran BLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-gjo (author)
Staaf, JohanLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-jst (author)
Berntsson, PiaLund University,Lunds universitet,Molekylär neurogenetik,Forskargrupper vid Lunds universitet,Biologiska institutionen,Naturvetenskapliga fakulteten,Molecular Neurogenetics,Lund University Research Groups,Department of Biology,Faculty of Science(Swepub:lu)zoof-pbe (author)
Oredsson, StinaLund University,Lunds universitet,Funktionell zoologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Functional zoology,Department of Biology,Faculty of Science(Swepub:lu)zoof-sor (author)
Alm, KerstiLund University,Lunds universitet,Biologiska institutionen,Naturvetenskapliga fakulteten,Department of Biology,Faculty of Science(Swepub:lu)ke7004al (author)
Biologiska institutionenNaturvetenskapliga fakulteten (creator_code:org_t)

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In:Cell Biology International: Wiley32, s. 1467-14771095-83551065-6995

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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