Knee dGEMRIC at 7 T : Comparison against 1.5 T and evaluation of T1-mapping methods

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Peterson, PernillaLund University,Lunds universitet,Medicinsk strålningsfysik, Malmö,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Malmö,Lund University Research Groups,Skåne University Hospital (författare)

Knee dGEMRIC at 7 T : Comparison against 1.5 T and evaluation of T1-mapping methods

Artikel/kapitelEngelska2018

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2018-05-16
Springer Science and Business Media LLC,2018

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LIBRIS-ID:oai:lup.lub.lu.se:0e93449b-a92b-406b-9265-19d08a3432fb
https://lup.lub.lu.se/record/0e93449b-a92b-406b-9265-19d08a3432fbURI
https://doi.org/10.1186/s12891-018-2071-1DOI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:art swepub-publicationtype
Ämneskategori:ref swepub-contenttype

Anmärkningar

Background: dGEMRIC (delayed Gadolinium Enhanced Magnetic Resonance Image of Cartilage) is a well-established technique for cartilage quality assessment in osteoarthritis at clinical field strengths. The method is robust, but requires injection of contrast agent and a cumbersome examination procedure. New non-contrast-agent-based techniques for cartilage quality assessment are currently being developed at 7 T. However, dGEMRIC remains an important reference technique during this development. The aim of this work was to compare T1 mapping for dGEMRIC at 7 T and 1.5 T, and to evaluate three T1-mapping methods at 7 T. Methods: The knee of 10 healthy volunteers and 9 patients with early signs of cartilage degradation were examined at 1.5 T and 7 T after a single (one) contrast agent injection (Gd-(DTPA)2-). Inversion recovery (IR) sequences were acquired at both field strengths, and at 7 T variable flip angle (VFA) and Look-Locker (LL) sequences were additionally acquired. T1 maps were calculated and average T1 values were estimated within superficial and deep regions-of-interest (ROIs) in the lateral and medial condyles, respectively. Results: T1 values were 1.8 (1.4-2.3) times longer at 7 T. A strong correlation was detected between 1.5 T and 7 T T1 values (r = 0.80). For IR, an additional inversion time was required to avoid underestimation (bias±limits of agreement - 127 ± 234 ms) due to the longer T1 values at 7 T. Out of the two 3D sequences tested, LL resulted in more accurate and precise T1 estimation compared to VFA (average bias±limits of agreement LL: 12 ± 202 ms compared to VFA: 25 ± 622 ms). For both, B1 correction improved agreement to IR. Conclusion: With an adapted sampling scheme, dGEMRIC T1 mapping is feasible at 7 T and correlates well to 1.5 T. If 3D is to be used for T1 mapping of the knee at 7 T, LL is preferred and VFA is not recommended. For VFA and LL, B1 correction is necessary for accurate T1 estimation.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Radiologi och bildbehandling hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Radiology, Nuclear Medicine and Medical Imaging hsv//eng
7 T
Cartilage
dGEMRIC
Inversion recovery
Look-locker
Variable flip angle

Biuppslag (personer, institutioner, konferenser, titlar ...)

Tiderius, Carl JohanLund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)orto-cti (författare)
Olsson, EmmaLund University,Lunds universitet,Medicinsk strålningsfysik, Malmö,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Malmö,Lund University Research Groups(Swepub:lu)em7443ol (författare)
Lundin, BjörnSkåne University Hospital(Swepub:lu)drad-blu (författare)
Olsson, Lars E.Lund University,Lunds universitet,Medicinsk strålningsfysik, Malmö,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)rfa-lol (författare)
Svensson, JonasLund University,Lunds universitet,Medicinsk strålningsfysik, Malmö,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)rfa-jsv (författare)
Medicinsk strålningsfysik, MalmöForskargrupper vid Lunds universitet (creator_code:org_t)

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Ingår i:BMC Musculoskeletal Disorders: Springer Science and Business Media LLC19:11471-2474

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Av författaren/redakt...: Peterson, Pernil ...; Tiderius, Carl J ...; Olsson, Emma; Lundin, Björn; Olsson, Lars E.; Svensson, Jonas

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