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Search: WFRF:(Iversen Ole Erik) > (2007-2009) > The Impact of Quadr...

  • Wheeler, Cosette M. (author)

The Impact of Quadrivalent Human Papillomavirus (HPV; Types 6, 11, 16, and 18) L1 Virus-Like Particle Vaccine on Infection and Disease Due to Oncogenic Nonvaccine HPV Types in Sexually Active Women Aged 16-26 Years

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • Oxford University Press (OUP),2009

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:0eba5f86-2ab0-430d-823f-618d499e7b85
  • https://lup.lub.lu.se/record/1404742URI
  • https://doi.org/10.1086/597309DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:118429424URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:kon swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background. We evaluated the impact of a quadrivalent human papillomavirus (HPV) vaccine on infection and cervical disease related to 10 nonvaccine HPV types (31, 33, 35, 39, 45, 51, 52, 56, 58, and 59) associated with >20% of cervical cancers. The population evaluated included HPV-naive women and women with preexisting HPV infection and/or HPV-related disease at enrollment. Methods. Phase 3 efficacy studies enrolled 17,622 women aged 16-26 years. Subjects underwent cervicovaginal sampling and Pap testing on day 1 and then at 6-12-month intervals for up to 4 years. HPV typing was performed on samples from enrollment and follow-up visits, including samples obtained for diagnosis or treatment of HPV-related disease. All subjects who received >= 1 dose and returned for follow-up were included. Results. Vaccination reduced the rate of HPV-31/33/45/52/58 infection by 17.7% (95% confidence interval [CI], 5.1% to 28.7%) and of cervical intraepithelial neoplasia (CIN) 1-3 or adenocarcinoma in situ (AIS) by 18.8% (95% CI, 7.4% to 28.9%). Vaccination also reduced the rate of HPV-31/58/59-related CIN1-3/AIS by 26.0% (95% CI, 6.7% to 41.4%), 28.1% (95% CI, 5.3% to 45.6%), and 37.6% (95% CI, 6.0% to 59.1%), respectively. Although a modest reduction in HPV-31/33/45/52/58-related CIN2 or worse was observed, the estimated reduction was not statistically significant. Conclusions. These cross-protection results complement the vaccine's prophylactic efficacy against disease associated with HPV-6, -11, -16, and - 18. Long-term monitoring of vaccinated populations are needed to fully ascertain the population-based impact and public health significance of these findings.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Kjaer, Susanne K. (author)
  • Sigurdsson, Kristjan (author)
  • Iversen, Ole-Erik (author)
  • Hernandez-Avila, Mauricio (author)
  • Perez, Gonzalo (author)
  • Brown, Darron R. (author)
  • Koutsky, Laura A. (author)
  • Tay, Eng Hseon (author)
  • Garcia, Patricia (author)
  • Ault, Kevin A. (author)
  • Garland, Suzanne M. (author)
  • Leodolter, Sepp (author)
  • Olsson, Sven-EricKarolinska Institutet (author)
  • Tang, Grace W. K. (author)
  • Ferris, Daron G. (author)
  • Paavonen, Jorma (author)
  • Steben, Marc (author)
  • Bosch, F. Xavier (author)
  • Dillner, JoakimKarolinska Institutet,Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups(Swepub:lu)mikr-jdi (author)
  • Joura, Elmar A. (author)
  • Kurman, Robert J. (author)
  • Majewski, Slawomir (author)
  • Munoz, Nubia (author)
  • Myers, Evan R. (author)
  • Villa, Luisa L. (author)
  • Taddeo, Frank J. (author)
  • Roberts, Christine (author)
  • Tadesse, Amha (author)
  • Bryan, Janine (author)
  • Lupinacci, Lisa C. (author)
  • Giacoletti, Katherine E. D. (author)
  • James, Margaret (author)
  • Vuocolo, Scott (author)
  • Hesley, Teresa M. (author)
  • Barr, Eliav (author)
  • Karolinska InstitutetKlinisk mikrobiologi, Malmö (creator_code:org_t)

Related titles

  • In:Journal Of Infectious Diseases: Oxford University Press (OUP)199:7, s. 936-9440022-18991537-6613

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