Combined lifestyle factors and the risk of LADA and type 2 diabetes – Results from a Swedish population-based case-control study

Aims: We investigated the risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes in relation to a healthy lifestyle, the proportion of patients attributable to an unhealthy lifestyle, and the influence of family history of diabetes (FHD) and genetic susceptibility. Methods: The population-based study included incident LADA (n = 571), type 2 diabetes (n = 1962), and matched controls (n = 2217). A healthy lifestyle was defined by BMI < 25 kg/m2, moderate-to-high physical activity, a healthy diet, no smoking, and moderate alcohol consumption. We estimated odds ratios (OR) with 95% confidence intervals (CIs) adjusted for age, sex, education, and FHD. Results: Compared to a poor/moderate lifestyle, a healthy lifestyle was associated with a reduced risk of LADA (OR 0.51, CI 0.34–0.77) and type 2 diabetes (OR 0.09, CI 0.05–0.15). A healthy lifestyle conferred a reduced risk irrespective of FHD and high-risk HLA genotypes. Having a BMI < 25 kg/m2 conferred the largest risk reduction for both LADA (OR 0.54, CI 0.43–0.66) and type 2 diabetes (OR 0.12, CI 0.10–0.15) out of the individual items. Conclusion: People with a healthy lifestyle, especially a healthy body weight, have a reduced risk of LADA including those with genetic susceptibility to diabetes.

Ahlqvist, EmmaLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups(Swepub:lu)infl-eah (författare)
Alfredsson, LarsKarolinska Institutet,Karolinska Institute (författare)
Groop, LeifLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups(Swepub:lu)endo-lgr (författare)
Hjort, RebeckaKarolinska Institutet,Karolinska Institute (författare)
Löfvenborg, Josefin E.Karolinska Institutet,Karolinska Institute (författare)
Tuomi, TiinamaijaLund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups,Helsinki University Central Hospital,University of Helsinki,Institute for Molecular Medicine Finland (FIMM)(Swepub:lu)ti8736tu (författare)
Carlsson, SofiaKarolinska Institutet,Karolinska Institute (författare)
Karolinska InstitutetKarolinska Institute (creator_code:org_t)

Ingår i:Diabetes Research and Clinical Practice: Elsevier BV1740168-82271872-8227

Av författaren/redakt...: Herzog, Katharin ...; Ahlqvist, Emma; Alfredsson, Lars; Groop, Leif; Hjort, Rebecka; Löfvenborg, Jose ...; visa fler...; Tuomi, Tiinamaij ...; Carlsson, Sofia; visa färre...

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