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TGF-β signaling in ...
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Blank Savukinas, UlrikaLund University,Lunds universitet,Avdelningen för molekylärmedicin och genterapi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Molecular Medicine and Gene Therapy,Department of Laboratory Medicine,Faculty of Medicine
(författare)
TGF-β signaling in the control of hematopoietic stem cells.
- Artikel/kapitelEngelska2015
Förlag, utgivningsår, omfång ...
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American Society of Hematology,2015
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:0f65137c-97c0-4095-ac85-3d5e4bc97197
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https://lup.lub.lu.se/record/5360288URI
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https://doi.org/10.1182/blood-2014-12-618090DOI
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Språk:engelska
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Sammanfattning på:engelska
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Blood is a tissue with high cellular turnover, and its production is a tightly orchestrated process that requires constant replenishment. All mature blood cells are generated from hematopoietic stem cells (HSCs), which are the self-renewing units that sustain life-long hematopoiesis. HSC behavior, such as self-renewal and quiescence, are regulated by a wide array of factors, including external signaling cues present in the bone marrow. The Transforming Growth Factor-β (TGF-β) family of cytokines constitutes a multifunctional signaling circuitry, which regulates pivotal functions related to cell fate and behavior in virtually all tissues of the body. In the hematopoietic system, TGF-β signaling controls a wide spectrum of biological processes, from homeostasis of the immune system to quiescence and self-renewal of HSCs. Here, we review key features and emerging concepts pertaining to TGF-β and downstream signaling pathways in normal HSC biology, featuring aspects of aging, hematological disease, and how this circuitry may be exploited for clinical purposes in the future.
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Karlsson, StefanLund University,Lunds universitet,Avdelningen för molekylärmedicin och genterapi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Molecular Medicine and Gene Therapy,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)molm-ska
(författare)
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Avdelningen för molekylärmedicin och genterapiInstitutionen för laboratoriemedicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Blood: American Society of Hematology125:23, s. 3542-35501528-00200006-4971
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Blood
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