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  • Yu, BingUniversity of Texas (författare)

Supplemental Association of Clonal Hematopoiesis With Incident Heart Failure

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2021
  • 11 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:0f7718ea-5e06-479a-ade2-6697aafc0d03
  • https://lup.lub.lu.se/record/0f7718ea-5e06-479a-ade2-6697aafc0d03URI
  • https://doi.org/10.1016/j.jacc.2021.04.085DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Background: Age-related clonal hematopoiesis of indeterminate potential (CHIP), defined as clonally expanded leukemogenic sequence variations (particularly in DNMT3A, TET2, ASXL1, and JAK2) in asymptomatic individuals, is associated with cardiovascular events, including recurrent heart failure (HF). Objectives: This study sought to evaluate whether CHIP is associated with incident HF. Methods: CHIP status was obtained from whole exome or genome sequencing of blood DNA in participants without prevalent HF or hematological malignancy from 5 cohorts. Cox proportional hazards models were performed within each cohort, adjusting for demographic and clinical risk factors, followed by fixed-effect meta-analyses. Large CHIP clones (defined as variant allele frequency >10%), HF with or without baseline coronary heart disease, and left ventricular ejection fraction were evaluated in secondary analyses. Results: Of 56,597 individuals (59% women, mean age 58 years at baseline), 3,406 (6%) had CHIP, and 4,694 developed HF (8.3%) over up to 20 years of follow-up. CHIP was prospectively associated with a 25% increased risk of HF in meta-analysis (hazard ratio: 1.25; 95% confidence interval: 1.13-1.38) with consistent associations across cohorts. ASXL1, TET2, and JAK2 sequence variations were each associated with an increased risk of HF, whereas DNMT3A sequence variations were not associated with HF. Secondary analyses suggested large CHIP was associated with a greater risk of HF (hazard ratio: 1.29; 95% confidence interval: 1.15-1.44), and the associations for CHIP on HF with and without prior coronary heart disease were homogenous. ASXL1 sequence variations were associated with reduced left ventricular ejection fraction. Conclusions: CHIP, particularly sequence variations in ASXL1, TET2, and JAK2, represents a new risk factor for HF.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Roberts, Mary B.Brown University (författare)
  • Raffield, Laura M.University of North Carolina (författare)
  • Zekavat, Seyedeh MaryamYale University,Broad Institute (författare)
  • Nguyen, Ngoc Quynh H.University of Texas (författare)
  • Biggs, Mary L.University of North Carolina,University of Washington (författare)
  • Brown, Michael R.University of Texas (författare)
  • Griffin, GabrielBroad Institute (författare)
  • Desai, PinkalWeill Cornell Medical College (författare)
  • Correa, AdolfoUniversity of Mississippi Medical Center (författare)
  • Morrison, Alanna C.University of Texas (författare)
  • Shah, Amil M.Brigham and Women's Hospital / Harvard Medical School (författare)
  • Niroula, AbhishekLund University,Lunds universitet,Hematogenomics,Forskargrupper vid Lunds universitet,Lund University Research Groups,Dana-Farber Cancer Institute,Broad Institute(Swepub:lu)med-anu (författare)
  • Uddin, Md MesbahBroad Institute (författare)
  • Honigberg, Michael C.Massachusetts General Hospital,Broad Institute,Harvard Medical School (författare)
  • Ebert, Benjamin L.Harvard Medical School,Brigham and Women's Hospital / Harvard Medical School,Howard Hughes Medical Institute (författare)
  • Psaty, Bruce M.Washington University School of Medicine (författare)
  • Whitsel, Eric A.University of North Carolina (författare)
  • Manson, Jo Ann E.Brigham and Women's Hospital / Harvard Medical School,Harvard Medical School (författare)
  • Kooperberg, CharlesFred Hutchinson Cancer Research Center (författare)
  • Bick, Alexander G.Vanderbilt University (författare)
  • Ballantyne, Christie M.Baylor College of Medicine (författare)
  • Reiner, Alex P.Fred Hutchinson Cancer Research Center (författare)
  • Natarajan, PradeepBroad Institute,Harvard Medical School,Massachusetts General Hospital (författare)
  • Eaton, Charles B.Brown University (författare)
  • University of TexasBrown University (creator_code:org_t)
  • National Heart, Lung, and Blood Institute TOPMed Consortium

Sammanhörande titlar

  • Ingår i:Journal of the American College of Cardiology: Elsevier BV78:1, s. 42-520735-1097

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