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- Mulder, HindrikLund University,Lunds universitet,Diabetes - molekylär metabolism,Forskargrupper vid Lunds universitet,Diabetes - Molecular Metabolism,Lund University Research Groups (author)
Pituitary adenylate cyclase-activating polypeptide and islet amyloid polypeptide in primary sensory neurons : Functional implications from plasticity in expression on nerve injury and inflammation
- Article/chapterEnglish1999
Publisher, publication year, extent ...
- 1999
- 25 s.
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:0f853371-d659-41a1-9a37-35561a98fa04
- https://lup.lub.lu.se/record/0f853371-d659-41a1-9a37-35561a98fa04URI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Primary sensory neurons serve a dual role as afferent neurons, conveying sensory information from the periphery to the central nervous system, and as efferent effectors mediating, e.g., neurogenic inflammation. Neuropeptides are crucial for both these mechanisms in primary sensory neurons. In afferent functions, they act as messengers and modulators in addition to a principal transmitter; by release from peripheral terminals, they induce an efferent response, 'neurogenic inflammation,' which comprises vasodilatation, plasma extravasation, and recruitment of immune cells. In this article, we introduce two novel members of the sensory neuropeptide family: pituitary adenylate cyclase-activating polypeptide (PACAP) and islet amyloid polypeptide (IAPP). Whereas PACAP, a vasoactive intestinal polypeptide-resembling peptide, predominantly occurs in neuronal elements, IAPP, which is structurally related to calcitonin gene-related peptide, is most widely known as a pancreatic β-cell peptide; as such, it has been recognized as a constituent of amyloid deposits in type 2 diabetes. In primary sensory neurons, under normal conditions, both peptides are predominantly expressed in small-sized nerve cell bodies, suggesting a role in nociception. On axotomy, the expression of PACAP is rapidly induced, whereas that of IAPP is reduced. Such a regulation of PACAP suggests that it serves a protective role during nerve injury, but that of IAPP may indicate that it is an excitatory messenger under normal conditions. In contrast, in localized adjuvant-induced inflammation, expression of both peptides is rapidly induced. For IAPP, studies in IAPP-deficient mice support the notion that IAPP is a pronociceptive peptide, because these mutant mice display a reduced nociceptive response when challenged with formalin.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
- Amylin
- Axotomy
- Freund's complete adjuvant
- IAPP
- In situ hybridization
- Knockout mice
- Neurogenic inflammation
- Neuropeptides
- PACAP
- β-cells
Added entries (persons, corporate bodies, meetings, titles ...)
- Jongsma, HelenLund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Neurala gränsytor,Forskargrupper vid Lunds universitet,Department of Experimental Medical Science,Faculty of Medicine,Neural Interfaces,Lund University Research Groups(Swepub:lu)mphy-hja (author)
- Zhang, YanzhenLund University (author)
- Gebre-Medhin, SamuelUniversity of Gothenburg(Swepub:lu)mphy-sgm (author)
- Sundler, FrankLund University,Lunds universitet,Neuroendokrin cellbiologi,Forskargrupper vid Lunds universitet,Neuroendocrine Cell Biology,Lund University Research Groups(Swepub:lu)mphy-fsu (author)
- Danielsen, NilsLund University,Lunds universitet,Neurala gränsytor,Forskargrupper vid Lunds universitet,Neuronano Research Center (NRC),Neural Interfaces,Lund University Research Groups(Swepub:lu)mphy-nda (author)
- Diabetes - molekylär metabolismForskargrupper vid Lunds universitet (creator_code:org_t)
Related titles
- In:Molecular Neurobiology19:3, s. 229-2530893-7648
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