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  • Gasparovic, Hrvoje (author)

Impact of progressive aortic regurgitation on outcomes after left ventricular assist device implantation

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-06-23
  • Springer Science and Business Media LLC,2022

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:113bb48c-9634-4157-8f7d-d57b8a3b8997
  • https://lup.lub.lu.se/record/113bb48c-9634-4157-8f7d-d57b8a3b8997URI
  • https://doi.org/10.1007/s00380-022-02111-1DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:150014361URI

Supplementary language notes

  • Language:English
  • Summary in:English

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Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Aortic regurgitation (AR) following continuous flow left ventricular assist device implantation (cf-LVAD) may adversely impact outcomes. We aimed to assess the incidence and impact of progressive AR after cf-LVAD on prognosis, biomarkers, functional capacity and echocardiographic findings. In an analysis of the PCHF-VAD database encompassing 12 European heart failure centers, patients were dichotomized according to the progression of AR following LVAD implantation. Patients with de-novo AR or AR progression (AR_1) were compared to patients without worsening AR (AR_0). Among 396 patients (mean age 53 ± 12 years, 82% male), 153 (39%) experienced progression of AR over a median of 1.4 years on LVAD support. Before LVAD implantation, AR_1 patients were less frequently diabetic, had lower body mass indices and higher baseline NT-proBNP values. Progressive AR did not adversely impact mortality (26% in both groups, HR 0.91 [95% CI 0.61–1.36]; P = 0.65). No intergroup variability was observed in NT-proBNP values and 6-minute walk test results at index hospitalization discharge and at 6-month follow-up. However, AR_1 patients were more likely to remain in NYHA class III and had worse right ventricular function at 6-month follow-up. Lack of aortic valve opening was related to de-novo or worsening AR (P < 0.001), irrespective of systolic blood pressure (P = 0.67). Patients commonly experience de-novo or worsening AR when exposed to continuous flow of contemporary LVADs. While reducing effective forward flow, worsening AR did not influence survival. However, less complete functional recovery and worse RV performance among AR_1 patients were observed. Lack of aortic valve opening was associated with progressive AR.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Jakus, Nina (author)
  • Brugts, Jasper J.Erasmus University Medical Center (author)
  • Pouleur, Anne CatherineSaint-Luc University Hospital,Catholic University of Louvain (author)
  • Timmermans, PhilippeUniversity Hospitals Leuven (author)
  • Rubiś, PawelJagiellonian University (author)
  • Gaizauskas, EdvinasVilnius University (author)
  • Van Craenenbroeck, Emeline M.Antwerp University Hospital (author)
  • Barge-Caballero, Eduardo (author)
  • Grundmann, Sebastian (author)
  • Paolillo, StefaniaUniversity of Naples Federico II (author)
  • D’Amario, Domenico (author)
  • Braun, OscarLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Heart Failure and Mechanical Support,Forskargrupper vid Lunds universitet,Molecular Epidemiology and Cardiology,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital(Swepub:lu)kard-oos (author)
  • Meyns, BartUniversity Hospitals Leuven (author)
  • Droogne, WalterUniversity Hospitals Leuven (author)
  • Wierzbicki, KarolJagiellonian University (author)
  • Holcman, KatarzynaJagiellonian University (author)
  • Planinc, Ivo (author)
  • Lovric, Daniel (author)
  • Flammer, Andreas J.University Hospital of Zurich (author)
  • Petricevic, Mate (author)
  • Biocina, Bojan (author)
  • Lund, Lars H.Karolinska Institutet,Karolinska Institute (author)
  • Milicic, Davor (author)
  • Ruschitzka, FrankUniversity Hospital of Zurich (author)
  • Cikes, Maja (author)
  • Erasmus University Medical CenterSaint-Luc University Hospital (creator_code:org_t)

Related titles

  • In:Heart and Vessels: Springer Science and Business Media LLC37:12, s. 1985-19940910-83271615-2573

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