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Dairy product intak...
Dairy product intake and risk of type 2 diabetes in EPIC-interact : A mendelian randomization study
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- Vissers, Linda E.T. (author)
- University Medical Center Utrecht
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- Sluijs, Ivonne (author)
- University Medical Center Utrecht,Utrecht University
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- van der Schouw, Yvonne T. (author)
- University Medical Center Utrecht,Utrecht University
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- Forouhi, Nita G. (author)
- University of Cambridge
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- Imamura, Fumiaki (author)
- University of Cambridge
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- Burgess, Stephen (author)
- University of Cambridge
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- Barricarte, Aurelio (author)
- Navarre Public Health Institute (ISPN)
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- Boeing, Heiner (author)
- German Institute of Human Nutrition
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- Bonet, Catalina (author)
- Catalan Institute of Oncology
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- Chirlaque, Maria Dolores (author)
- University of Murcia,Murcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP)
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- Fagherazzi, Guy (author)
- Centre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay,Institut Gustave Roussy
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- Franks, Paul W. (author)
- Umeå universitet,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Avdelningen för medicin
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- Freisling, Heinz (author)
- International Agency for Research on Cancer, World Health Organization
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- Gunter, Marc J. (author)
- International Agency for Research on Cancer, World Health Organization
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- Ramón Quirós, J. (author)
- Public Health Directorate
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- Ibsen, Daniel B. (author)
- Aarhus University
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- Kaaks, Rudolf (author)
- German Cancer Research Centre
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- Key, Timothy (author)
- University of Oxford,University of Cambridge
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- Khaw, Kay T. (author)
- University of Cambridge
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- Kühn, Tilman (author)
- German Cancer Research Centre
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- Mokoroa, Olatz (author)
- Biodonostia Health Research Institute,CIBER Epidemiology and Public Health (CIBERESP)
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- Nilsson, Peter M. (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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- Overvad, Kim (author)
- Aalborg University
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- Pala, Valeria (author)
- Istituto Nazionale dei Tumori
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- Palli, Domenico (author)
- Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
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- Panico, Salvatore (author)
- University of Naples Federico II
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- Sacerdote, Carlotta (author)
- Citta' della Salute e della Scienza Hospital-University of Turin
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- Spijkerman, Annemieke M.W. (author)
- National Institute for Public Health and the Environment (RIVM)
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- Tjonneland, Anne (author)
- Danish Cancer Society
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- Tumino, Rosario (author)
- Civic and M.P Arezzo Hospital
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- Rodríguez-Barranco, Miguel (author)
- University of Granada,Hospital Clínico Universitario San Cecilio
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- Rolandsson, Olov (author)
- Umeå universitet,Umeå University,Allmänmedicin
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- Riboli, Elio (author)
- Imperial College London
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- Sharp, Stephen J. (author)
- University of Cambridge
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- Langenberg, Claudia (author)
- University of Cambridge
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- Wareham, Nicholas J. (author)
- University of Cambridge
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(creator_code:org_t)
- 2019-02-06
- 2019
- English 8 s.
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In: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 42:4, s. 568-575
- Related links:
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http://dx.doi.org/10...
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https://care.diabete...
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https://lup.lub.lu.s...
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https://doi.org/10.2...
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https://urn.kb.se/re...
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Abstract
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- OBJECTIVE To estimate the causal association between intake of dairy products and incident type 2 diabetes. RESEARCH DESIGN AND METHODS The analysis included 21,820 European individuals (9,686 diabetes cases) of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study. Participants were genotyped, and rs4988235 (LCT-12910C>T), a single nucleotide polymorphism (SNP) for lactase persistence (LP) that enables digestion of dairy sugar, i.e., lactose, was imputed. Baseline dietary intakes were assessed with diet questionnaires. We investigated the associations between imputed SNP dosage for rs4988235 and intake of dairy products and other foods through linear regression. Mendelian randomization (MR) estimates for the milk-diabetes relationship were obtained through a two-stage least squares regression. RESULTS Each additional LP allele was associated with a higher intake of milk (b 17.1 g/day, 95% CI 10.6–23.6) and milk beverages (b 2.8 g/day, 95% CI 1.0–4.5) but not with intake of other dairy products. Other dietary intakes associated with rs4988235 included fruits (b 27.0 g/day, 95% CI 212.4 to 21.7 per additional LP allele), nonalcoholic beverages (b 218.0 g/day, 95% CI 234.4 to 21.6), and wine (b 24.8 g/day, 95% CI 29.1 to 20.6). In instrumental variable analysis, LP-associated milk intake was not associated with diabetes (hazard ratio per 15 g/day 0.99, 95% CI 0.93–1.05). CONCLUSIONS rs4988235 was associated with milk intake but not with intake of other dairy products. This MR study does not suggest that milk intake is associated with diabetes, which is consistent with previous observational and genetic associations. LP may be associated with intake of other foods as well, but owing to the modest associations, we consider it unlikely that this caused the observed null result.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Vissers, Linda E ...
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Sluijs, Ivonne
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van der Schouw, ...
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Forouhi, Nita G.
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Imamura, Fumiaki
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Burgess, Stephen
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show more...
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Barricarte, Aure ...
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Boeing, Heiner
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Bonet, Catalina
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Chirlaque, Maria ...
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Fagherazzi, Guy
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Franks, Paul W.
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Freisling, Heinz
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Gunter, Marc J.
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Ramón Quirós, J.
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Ibsen, Daniel B.
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Kaaks, Rudolf
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Key, Timothy
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Khaw, Kay T.
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Kühn, Tilman
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Mokoroa, Olatz
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Nilsson, Peter M ...
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Overvad, Kim
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Pala, Valeria
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Palli, Domenico
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Panico, Salvator ...
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Sacerdote, Carlo ...
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Spijkerman, Anne ...
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Tjonneland, Anne
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Tumino, Rosario
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Rodríguez-Barran ...
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Rolandsson, Olov
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Riboli, Elio
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Sharp, Stephen J ...
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Langenberg, Clau ...
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Wareham, Nichola ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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Diabetes Care
- By the university
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Lund University
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Umeå University