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What's normal? Immu...
What's normal? Immune profiling of human milk from healthy women living in different geographical and socioeconomic settings
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- Ruiz-Pavon, Lorena (författare)
- Complutense University of Madrid
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- Espinosa-Martos, Irene (författare)
- Complutense University of Madrid
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- García-Carral, Cristina (författare)
- Complutense University of Madrid
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- Manzano, Susana (författare)
- Complutense University of Madrid
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- McGuire, Michelle K. (författare)
- Washington State University
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- Meehan, Courtney L. (författare)
- Washington State University
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- McGuire, Mark A. (författare)
- University of Idaho
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- Williams, Janet E. (författare)
- University of Idaho
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- Foster, James (författare)
- University of Idaho
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- Sellen, Daniel W. (författare)
- University of Toronto
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- Kamau-Mbuthia, Elizabeth W. (författare)
- Egerton University
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- Kamundia, Egidioh W. (författare)
- Egerton University
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- Mbugua, Samwel (författare)
- Egerton University
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- Moore, Sophie E. (författare)
- King's College London,Medical Research Council Laboratories Gambia
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- Kvist, Linda J. (författare)
- Lund University,Lunds universitet,Barns och familjers hälsa,Forskargrupper vid Lunds universitet,Child and Family Health,Lund University Research Groups
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- Otoo, Gloria E. (författare)
- University of Ghana
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- Lackey, Kimberly A. (författare)
- Washington State University
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- Flores, Katherine (författare)
- Washington State University
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- Pareja, Rossina G. (författare)
- Instituto de Investigacion Nutricional Lima
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- Bode, Lars (författare)
- University of California, San Diego
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- Rodíguez, Juan M. (författare)
- Complutense University of Madrid
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(creator_code:org_t)
- 2017-06-30
- 2017
- Engelska.
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Ingår i: Frontiers in Immunology. - : Frontiers Media SA. - 1664-3224. ; 8:JUN
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.frontier...
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Human milk provides a very wide range of nutrients and bioactive components, including immune factors, human milk oligosaccharides, and a commensal microbiota. These factors are essential for interconnected processes including immunity programming and the development of a normal infant gastrointestinal microbiome. Newborn immune protection mostly relies on maternal immune factors provided through milk. However, studies dealing with an in-depth profiling of the different immune compounds present in human milk and with the assessment of their natural variation in healthy women from different populations are scarce. In this context, the objective of this work was the detection and quantification of a wide array of immune compounds, including innate immunity factors (IL1ß, IL6, IL12, INFγ, TNFα), acquired immunity factors (IL2, IL4, IL10, IL13, IL17), chemokines (IL8, Groα, MCP1, MIP1ß), growth factors [IL5, IL7, epidermal growth factor (EGF), granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, TGFß2], and immunoglobulins (IgA, IgG, IgM), in milk produced by healthy women of different ethnicities living in different geographic, dietary, socioeconomic, and environmental settings. Among the analyzed factors, IgA, IgG, IgM, EGF, TGFß2, IL7, IL8, Groa, and MIP1ß were detected in all or most of the samples collected in each population and, therefore, this specific set of compounds might be considered as the "core" soluble immune factors in milk produced by healthy women worldwide. This approach may help define which immune factors are (or are not) common in milk produced by women living in various conditions, and to identify host, lifestyle, and environmental factors that affect the immunological composition of this complex biological fluid.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Breastfeeding
- Chemokines
- Cytokines
- Growth factors
- Human milk
- Immunoglobulins
- Lactation
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Ruiz-Pavon, Lore ...
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Espinosa-Martos, ...
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García-Carral, C ...
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Manzano, Susana
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McGuire, Michell ...
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Meehan, Courtney ...
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visa fler...
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McGuire, Mark A.
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Williams, Janet ...
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Foster, James
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Sellen, Daniel W ...
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Kamau-Mbuthia, E ...
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Kamundia, Egidio ...
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Mbugua, Samwel
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Moore, Sophie E.
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Kvist, Linda J.
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Otoo, Gloria E.
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Lackey, Kimberly ...
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Flores, Katherin ...
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Pareja, Rossina ...
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Bode, Lars
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Rodíguez, Juan M ...
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