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  • Hanly, John G.Dalhousie University (author)

Neuropsychiatric Events in Systemic Lupus Erythematosus : Predictors of Occurrence and Resolution in a Longitudinal Analysis of an International Inception Cohort

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-10-29
  • Wiley,2021

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:11f2c620-a83e-4e4f-936a-5b333457eb01
  • https://lup.lub.lu.se/record/11f2c620-a83e-4e4f-936a-5b333457eb01URI
  • https://doi.org/10.1002/art.41876DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Objective: To determine predictors of change in neuropsychiatric (NP) event status in a large, prospective, international inception cohort of patients with systemic lupus erythematosus (SLE). Methods: Upon enrollment and annually thereafter, NP events attributed to SLE and non-SLE causes and physician-determined resolution were documented. Factors potentially associated with the onset and resolution of NP events were determined by time-to-event analysis using a multistate modeling structure. Results: NP events occurred in 955 (52.3%) of 1,827 patients, and 593 (31.0%) of 1,910 unique events were attributed to SLE. For SLE-associated NP (SLE NP) events, multivariate analysis revealed a positive association with male sex (P = 0.028), concurrent non-SLE NP events excluding headache (P < 0.001), active SLE (P = 0.012), and glucocorticoid use (P = 0.008). There was a negative association with Asian race (P = 0.002), postsecondary education (P = 0.001), and treatment with immunosuppressive drugs (P = 0.019) or antimalarial drugs (P = 0.056). For non-SLE NP events excluding headache, there was a positive association with concurrent SLE NP events (P < 0.001) and a negative association with African race (P = 0.012) and Asian race (P < 0.001). NP events attributed to SLE had a higher resolution rate than non-SLE NP events, with the exception of headache, which had comparable resolution rates. For SLE NP events, multivariate analysis revealed that resolution was more common in patients of Asian race (P = 0.006) and for central/focal NP events (P < 0.001). For non-SLE NP events, resolution was more common in patients of African race (P = 0.017) and less common in patients who were older at SLE diagnosis (P < 0.001). Conclusion: In a large and long-term study of the occurrence and resolution of NP events in SLE, we identified subgroups with better and worse prognosis. The course of NP events differs greatly depending on their nature and attribution.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Gordon, CarolineUniversity of Birmingham (author)
  • Bae, Sang CheolHanyang University (author)
  • Romero-Diaz, JuanitaSalvador Zubirán National Institute of Health Sciences and Nutrition (author)
  • Sanchez-Guerrero, JorgeSalvador Zubirán National Institute of Health Sciences and Nutrition (author)
  • Bernatsky, SashaMcGill University (author)
  • Clarke, Ann E.University of Calgary (author)
  • Wallace, Daniel J.Cedars-Sinai Medical Center (author)
  • Isenberg, David A.University College London (author)
  • Rahman, AnisurUniversity College London (author)
  • Merrill, Joan TOklahoma Medical Research Foundation (author)
  • Fortin, Paul R.Laval University (author)
  • Gladman, Dafna D.University of Toronto (author)
  • Urowitz, Murray B.University of Toronto (author)
  • Bruce, Ian N.University of Manchester (author)
  • Petri, MichelleJohns Hopkins University School of Medicine (author)
  • Ginzler, Ellen M.SUNY Downstate Health Sciences University (author)
  • Dooley, M. A.University of North Carolina (author)
  • Ramsey-Goldman, RosalindNorthwestern University Feinberg School of Medicine (author)
  • Manzi, SusanAllegheny Health Network (author)
  • Jonsen, AndreasLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups(Swepub:lu)reum-ajo (author)
  • Alarcón, Graciela S.University of Alabama (author)
  • van Vollenhoven, Ronald F.Academic Medical Center of University of Amsterdam (AMC) (author)
  • Aranow, CynthiaFeinstein Institute for Medical Research (author)
  • Mackay, MegganFeinstein Institute for Medical Research (author)
  • Ruiz-Irastorza, GuillermoUniversity of the Basque Country (author)
  • Lim, S. SamEmory University (author)
  • Inanc, MuratIstanbul University (author)
  • Kalunian, Kenneth C.University of California, San Diego (author)
  • Jacobsen, SorenCopenhagen University Hospital (author)
  • Peschken, Christine AUniversity of Manitoba (author)
  • Kamen, Diane L.Medical University of South Carolina (author)
  • Askanase, AncaNYU Langone (author)
  • Farewell, VernonUniversity of Cambridge (author)
  • Dalhousie UniversityUniversity of Birmingham (creator_code:org_t)

Related titles

  • In:Arthritis and Rheumatology: Wiley73:12, s. 2293-23022326-51912326-5205

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