id:"swepub:oai:lup.lub.lu.se:12116a92-78a9-4e79-b5b2-bdfd53bcd199"
Search: id:"swepub:oai:lup.lub.lu.se:12116a92-78a9-4e79-b5b2-bdfd53bcd199" > Helicobacter specie...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Casswall, Thomas H.Karolinska Institutet (author)
Helicobacter species DNA in liver and gastric tissues in children and adolescents with chronic liver disease
- Article/chapterEnglish2010
Publisher, publication year, extent ...
- 2010-01-23
- Informa UK Limited,2010
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:12116a92-78a9-4e79-b5b2-bdfd53bcd199
- https://lup.lub.lu.se/record/1547156URI
- https://doi.org/10.3109/00365520903426915DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:119939005URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Objective. Enterohepatic Helicobacter species (EHS) have previously been found in adults with hepatobiliary diseases. Here, we report the prevalence of Helicobacter pylori and EHS in liver and gastric tissue in children and adolescents with chronic liver disease (CLD). Material and methods. Seventy-seven consecutive children and adolescents with CLD with or without ulcerative colitis or Crohn's disease (UC/CD) were investigated. Tissue samples were analysed using a Helicobacter genus specific 16S rDNA polymerase chain reaction (PCR) assay and DNA-sequence analysis. Sera from 61 subjects were also analysed using enzyme immunoassay and immunoblotting. Results. The Helicobacter PCR was positive in 3/23 (13%) livers from patients with primary sclerosing cholangitis and UC, and in 1/2 livers from patients with autoimmune hepatitis (AIH) and UC. Sequenced PCR products matched the 16S rDNA of H. hepaticus, H. muridarum, H. canis, and H. pylori, respectively. H. ganmani and H. bilis were detected in gastric tissues from two AIH patients. H. hepaticus and H. pullorum were found in livers from two patients with acute liver failure and intrahepatic cholestasis. Antibody reactivity to Helicobacter cell-surface proteins was negative. Conclusions. H. pylori and EHS can be detected in the livers of some patients with UC and concomitant liver disease, as well as in other children with liver diseases. Multicentre studies from different locations are needed to find out whether these bacteria play a pathogenetic role or whether their presence is an epiphenomenon.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Gastroenterologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Gastroenterology and Hepatology hsv//eng
- colitis
- ulcerative
- primary sclerosing cholangitis
- polymerase chain reaction
- liver tissue
- inflammatory bowel disease
- Helicobacter pylori
- enterohepatic Helicobacter species
- Autoimmune hepatitis
- children
Added entries (persons, corporate bodies, meetings, titles ...)
- Nemeth, AntalKarolinska Institutet (author)
- Nilsson, IngridLund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)mmb-ini (author)
- Wadström, TorkelLund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)mmb-twa (author)
- Nilsson, Hans-OlofLund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)mmb-hon (author)
- Karolinska InstitutetAvdelningen för medicinsk mikrobiologi (creator_code:org_t)
Related titles
- In:Scandinavian Journal of Gastroenterology: Informa UK Limited45:2, s. 160-1671502-77080036-5521
Internet link
Find in a library
- Scandinavian Journal of Gastroenterology (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Casswall, Thomas ...
- Nemeth, Antal
- Nilsson, Ingrid
- Wadström, Torkel
- Nilsson, Hans-Ol ...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Gastroenterology ...
- Articles in the publication
- Scandinavian Jou ...
- By the university
- Lund University
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
