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Sökning: onr:"swepub:oai:lup.lub.lu.se:12b2cf65-db96-4391-840a-ffc5eb7a2eda" > Factors That Increa...

  • Kemppainen, Kaisa MUniversity of Florida (författare)

Factors That Increase Risk of Celiac Disease Autoimmunity After a Gastrointestinal Infection in Early Life

  • Artikel/kapitelEngelska2017

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2017

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:12b2cf65-db96-4391-840a-ffc5eb7a2eda
  • https://lup.lub.lu.se/record/12b2cf65-db96-4391-840a-ffc5eb7a2edaURI
  • https://doi.org/10.1016/j.cgh.2016.10.033DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Background & Aims: Little is known about the pathogenic mechanisms of gluten immunogenicity in patients with celiac disease. We studied temporal associations between infections and the development of celiac disease autoimmunity, and examined effects of HLA alleles, rotavirus vaccination status, and infant feeding. Methods: We monitored 6327 children in the United States and Europe carrying HLA risk genotypes for celiac disease from 1 to 4 years of age for presence of tissue transglutaminase autoantibodies (the definition of celiac disease autoimmunity), until March 31, 2015. Parental reports of gastrointestinal and respiratory infections were collected every third month from birth. We analyzed time-varying relationships among reported infections, rotavirus vaccination status, time to first introduction of gluten, breastfeeding, and risk of celiac disease autoimmunity using proportional hazard models. Results: We identified 13,881 gastrointestinal infectious episodes (GIE) and 79,816 respiratory infectious episodes. During the follow-up period, 732 of 6327 (11.6%) children developed celiac disease autoimmunity. A GIE increased the risk of celiac disease autoimmunity within the following 3 months by 33% (hazard ratio [HR], 1.33; 95% confidence interval [CI], 1.11-1.59). This risk increased 2-fold among children born in winter and introduced to gluten before age 6 months (HR, 2.08; 95% CI, 1.46-2.98), and increased 10-fold among children without HLA-DQ2 alleles and breastfed for fewer than 4 months (HR, 9.76; 95% CI, 3.87-24.8). Risk of celiac disease autoimmunity was reduced in children vaccinated against rotavirus and introduced to gluten before age 6 months (HR, 0.57; 95% CI, 0.36-0.88). Conclusions: Gastrointestinal infections increase the risk of celiac disease autoimmunity in children with genetic susceptibility to this autoimmune disorder. The risk is modified by HLA genotype, infant gluten consumption, breastfeeding, and rotavirus vaccination, indicating complex interactions among infections, genetic factors, and diet in the etiology of celiac disease in early childhood.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Lynch, Kristian F.University of South Florida(Swepub:lu)endo-kly (författare)
  • Liu, EdwinUniversity of Colorado (författare)
  • Lönnrot, MariaUniversity of Tampere (författare)
  • Simell, VilleUniversity of Turku (författare)
  • Briese, ThomasColumbia University (författare)
  • Koletzko, SibylleLudwig-Maximilian University of Munich (författare)
  • Hagopian, WilliamPacific Northwest Research Institute (författare)
  • Rewers, MarianUniversity of Colorado (författare)
  • She, Jin-XiongUniversity of Georgia (författare)
  • Simell, OlliUniversity of Turku (författare)
  • Toppari, JormaUniversity of Turku (författare)
  • Ziegler, Anette-GTechnical University of Munich (författare)
  • Akolkar, BeenaNational Institute of Diabetes and Digestive and Kidney Diseases (författare)
  • Krischer, Jeffrey PUniversity of South Florida (författare)
  • Lernmark, ÅkeLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups(Swepub:lu)endo-ale (författare)
  • Hyöty, HeikkiUniversity of Tampere (författare)
  • Triplett, Eric WUniversity of Florida (författare)
  • Agardh, DanielLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups(Swepub:lu)med-dia (författare)
  • University of FloridaUniversity of South Florida (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Clinical Gastroenterology and Hepatology: Elsevier BV15:5, s. 5-7021542-3565

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