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Sökning: WFRF:(Gudmundsdotter Lindvi) > Short-term HIV-1 tr...

  • Nowroozalizadeh, Salma (författare)

Short-term HIV-1 treatment interruption is associated with dysregulated TLR-stimuli responsiveness.

  • Artikel/kapitelEngelska2013

Förlag, utgivningsår, omfång ...

  • 2014-10-27
  • Informa UK Limited,2013

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:12d60b1a-7474-4bac-ae5a-2fb70a7bb2c7
  • https://lup.lub.lu.se/record/4935405URI
  • https://doi.org/10.4161/hv.25154DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:128201624URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Viremia during human immunodeficiency virus type-1 (HIV-1) infection results in progressive impairment of several components of the immune system. Here a unique model of repeated treatment interruptions (TIs) was used with the aim to reveal the effect of controlled short-term viremia on innate stimuli responsiveness and circulating dendritic cells (DCs). Sequential peripheral blood samples from HIV-1-infected patients on combination antiretroviral therapy, subjected to repeated TI cycles as part of a therapeutic DNA vaccination study, were analyzed. In vitro responsiveness of peripheral blood mononuclear cells to toll-like receptor (TLR) stimuli was analyzed by cytokine secretion, and frequencies of plasmacytoid DCs (pDCs) and myeloid DCs (mDCs) were monitored by flow cytometry. These parameters were found not to be significantly different between the vaccinated and placebo groups. Instead, independent of vaccination altered in vitro TLR responsiveness was observed in parallel with TI cycles. TLR7/8-triggered secretion of IL-12 and IFN-α, as well as TLR9-triggered secretion of IL-12, was hyperactivated. In contrast, expression of IFN-α after TLR9 stimulation decreased during the initial cycle of TI. Reduced frequencies of pDCs and mDCs, compared with baseline, were noted before and during the second TI, respectively. Furthermore, spontaneous ex vivo release of IL-12 from PBMC was noted during cycles of TI. In conclusion, these results suggest that consequences of short-term TI include dysregulated TLR responses and fluctuations in the frequencies of circulating DCs. Knowledge of these immunological factors may influence the continuation of stringent treatment schedules during HIV infections.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Gudmundsdotter, Lindvi (författare)
  • Hejdeman, BoKarolinska Institutet (författare)
  • Andersson, Lena (författare)
  • Esbjörnsson, JoakimLund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine(Swepub:lu)med-jes (författare)
  • Medstrand, PatrikLund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine(Swepub:lu)mmb-pme (författare)
  • Sandström, Eric (författare)
  • Gaines, Hans (författare)
  • Wahren, BrittaKarolinska Institutet (författare)
  • Jansson, MarianneKarolinska Institutet,Lund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)mmb-mj0 (författare)
  • Karolinska InstitutetInstitutionen för experimentell medicinsk vetenskap (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Human Vaccines & Immunotherapeutics: Informa UK Limited9:10, s. 2103-21102164-55152164-554X

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