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Emerging roles of i...
Emerging roles of innate lymphoid cells in inflammatory diseases : Clinical implications
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- Kortekaas Krohn, I. (author)
- Catholic University of Leuven
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- Shikhagaie, M. M. (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Golebski, K. (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Bernink, J. H. (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Breynaert, C. (author)
- University Hospitals Leuven
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- Creyns, B. (author)
- Catholic University of Leuven
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- Diamant, Z. (author)
- Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,University Medical Center Groningen
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- Fokkens, W. J. (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Gevaert, P. (author)
- Ghent University
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- Hellings, P. (author)
- University Hospitals Leuven
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Hendriks, R. W. (author)
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- Klimek, L. (author)
- Center for Rhinology and Allergology
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- Mjösberg, J. (author)
- Karolinska Institutet,Karolinska Institute
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- Morita, H. (author)
- National Center for Child Health and Development
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- Ogg, G. S. (author)
- University of Oxford
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- O'Mahony, L. (author)
- University of Zurich
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- Schwarze, J. (author)
- University of Edinburgh
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- Seys, S. F. (author)
- Catholic University of Leuven
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- Shamji, M. H. (author)
- Imperial College London,MRC Human Nutrition Research
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- Bal, S. M. (author)
- Academic Medical Center of University of Amsterdam (AMC)
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(creator_code:org_t)
- 2017-11-22
- 2018
- English.
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In: Allergy: European Journal of Allergy and Clinical Immunology. - : Wiley. - 0105-4538 .- 1398-9995. ; 73:4, s. 837-850
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Abstract
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- Innate lymphoid cells (ILC) represent a group of lymphocytes that lack specific antigen receptors and are relatively rare as compared to adaptive lymphocytes. ILCs play important roles in allergic and nonallergic inflammatory diseases due to their location at barrier surfaces within the airways, gut, and skin, and they respond to cytokines produced by activated cells in their local environment. Innate lymphoid cells contribute to the immune response by the release of cytokines and other mediators, forming a link between innate and adaptive immunity. In recent years, these cells have been extensively characterized and their role in animal models of disease has been investigated. Data to translate the relevance of ILCs in human pathology, and the potential role of ILCs in diagnosis, as biomarkers and/or as future treatment targets are also emerging. This review, produced by a task force of the Immunology Section of the European Academy of Allergy and Clinical Immunology (EAACI), encompassing clinicians and researchers, highlights the role of ILCs in human allergic and nonallergic diseases in the airways, gastrointestinal tract, and skin, with a focus on new insights into clinical implications, therapeutic options, and future research opportunities.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- Allergy
- Inflammatory diseases
- Innate lymphoid cells
- Therapeutic targets
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- By the author/editor
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Kortekaas Krohn, ...
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Shikhagaie, M. M ...
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Golebski, K.
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Bernink, J. H.
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Breynaert, C.
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Creyns, B.
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show more...
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Diamant, Z.
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Fokkens, W. J.
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Gevaert, P.
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Hellings, P.
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Hendriks, R. W.
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Klimek, L.
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Mjösberg, J.
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Morita, H.
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Ogg, G. S.
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O'Mahony, L.
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Schwarze, J.
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Seys, S. F.
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Shamji, M. H.
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Bal, S. M.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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Allergy: Europea ...
- By the university
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Lund University
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Karolinska Institutet