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Typical and atypica...
Typical and atypical carcinoid tumors of the lung : a clinicopathological correlation of 783 cases with emphasis on histological features
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- Moran, Cesar A. (author)
- University of Texas MD Anderson Cancer Center
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- Lindholm, Kaleigh E. (author)
- University of Texas MD Anderson Cancer Center
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- Brunnström, Hans (author)
- Lund University,Lunds universitet,Institutionen för laboratoriemedicin,Medicinska fakulteten,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Department of Laboratory Medicine,Faculty of Medicine,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Langman, Gerald (author)
- Heart of England NHS Foundation Trust
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- Jang, Se Jin (author)
- University of Ulsan
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- Spagnolo, Dominic (author)
- University of Notre Dame Australia,University of Western Australia, Perth
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- Chai, Siaw Ming (author)
- University of Western Australia, Perth
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- Laycock, Andrew (author)
- University of Notre Dame Australia,University of Western Australia, Perth
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- Falconieri, Giovanni (author)
- University Hospital of Udine
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- Pizzolitto, Stefano (author)
- University Hospital of Udine
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- de Pellegrin, Alessandro (author)
- University Hospital of Udine
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- Medeiros, Filomena (author)
- Basildon and Thurrock University Hospitals
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- Edmunds, Lilian (author)
- Basildon and Thurrock University Hospitals
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- Catarino, Ana (author)
- Hospital da Luz
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- Cunha, Fernando (author)
- Portuguese Institute Of Oncology
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- Ro, Jae (author)
- Methodist Hospital Houston
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- Pina-Oviedo, Sergio (author)
- University of Arkansas for Medical Sciences
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- Torrealba, Jose (author)
- University of Texas Southwestern Medical Center
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- Coppola, Domenico (author)
- H. Lee Moffitt Cancer Center & Research Institute
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- Petersson, Fredrik (author)
- National University Hospital
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- Oon, Ming Lian (author)
- National University Hospital
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- Elmberger, Goran (author)
- Norrland University Hospital
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- y Cajal, Santiago Ramon (author)
- Vall d'Hebron University Hospital
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- Valero, Irene Sansano (author)
- Vall d'Hebron University Hospital
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- Dalurzo, Liliana (author)
- Italian Hospital Of Buenos Aires
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- Soares, Fernando (author)
- A. C. Camargo Cancer Center
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- Campos, Antonio H. (author)
- A. C. Camargo Cancer Center
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- Vranic, Semir (author)
- Qatar University
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- Skenderi, Faruk (author)
- University Clinical Centre Sarajevo
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- Correa, Arlene M. (author)
- University of Texas MD Anderson Cancer Center
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- Sepesi, Boris (author)
- University of Texas MD Anderson Cancer Center
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- Rice, David (author)
- University of Texas MD Anderson Cancer Center
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- Mehran, Reza (author)
- University of Texas MD Anderson Cancer Center
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- Walsh, Garrett (author)
- University of Texas MD Anderson Cancer Center
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English 12 s.
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In: Human Pathology. - : Elsevier BV. - 0046-8177. ; 98, s. 98-109
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- We present 783 surgical resections of typical and atypical carcinoid tumors of the lung identified in the pathology files of 20 different pathology departments. All cases were critically reviewed for clinical and pathological features and further correlated with clinical outcomes. Long-term follow-up was obtained in all the patients and statistically analyzed to determine significance of the different parameters evaluated. Of the histopathological features analyzed, the presence of mitotic activity of 4 mitoses or more per 2 mm2, necrosis, lymphatic invasion, and lymph node metastasis were identified as statistically significant. Tumors measuring 3 cm or more were also identified as statistically significant and correlated with clinical outcomes. Based on our analysis, we consider that the separation of low- and intermediate-grade neuroendocrine neoplasms of the lung needs to be readjusted in terms of mitotic count as the risk of overgrading these neoplasms exceeds 10% under the current criteria. We also consider that tumor size is an important feature to be considered in the assessment of these neoplasms and together with the histological grade of the tumor offers important features that can be correlated with clinical outcomes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Atypical carcinoid
- Carcinoid
- Intermediate grade
- Low grade
- Lung
- Neuroendocrine
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Moran, Cesar A.
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Lindholm, Kaleig ...
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Brunnström, Hans
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Langman, Gerald
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Jang, Se Jin
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Spagnolo, Domini ...
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show more...
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Chai, Siaw Ming
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Laycock, Andrew
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Falconieri, Giov ...
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Pizzolitto, Stef ...
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de Pellegrin, Al ...
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Medeiros, Filome ...
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Edmunds, Lilian
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Catarino, Ana
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Cunha, Fernando
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Ro, Jae
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Pina-Oviedo, Ser ...
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Torrealba, Jose
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Coppola, Domenic ...
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Petersson, Fredr ...
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Oon, Ming Lian
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Elmberger, Goran
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y Cajal, Santiag ...
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Valero, Irene Sa ...
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Dalurzo, Liliana
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Soares, Fernando
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Campos, Antonio ...
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Vranic, Semir
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Skenderi, Faruk
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Correa, Arlene M ...
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Sepesi, Boris
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Rice, David
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Mehran, Reza
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Walsh, Garrett
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Human Pathology
- By the university
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Lund University