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MITF Modulates Ther...
MITF Modulates Therapeutic Resistance through EGFR Signaling.
- Article/chapterEnglish2015
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LIBRIS-ID:oai:lup.lub.lu.se:153b40d7-0b28-4c7e-813b-0dbca621ac6a
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https://lup.lub.lu.se/record/5258062URI
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https://doi.org/10.1038/jid.2015.105DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Response to targeted therapies varies significantly despite shared oncogenic mutations. Nowhere is this more apparent than in BRAF(V600E)-mutated melanomas where initial drug response can be striking and yet relapse is commonplace. Resistance to BRAF inhibitors have been attributed to the activation of various receptor tyrosine kinases (RTKs) though the underlying mechanisms have been largely uncharacterized. Here, we found that EGFR induced vemurafenib resistance is ligand dependent. We then employed whole-genome expression analysis and discovererd that vemurafenib resistance correlated with the loss of MITF, along with its melanocyte lineage program, and with the activation of EGFR signaling. An inverse relationship between MITF, vemurafenib resistance and EGFR was then observed in patient samples of recurrent melanoma and was conserved across melanoma cell lines and patients' tumor specimens. Functional studies revealed that MITF depletion activated EGFR signaling and consequently recapitulated the resistance phenotype. In contrast, forced expression of MITF in melanoma and colon cancer cells inhibited EGFR and conferred sensitivity to BRAF/MEK inhibitors. These findings indicate that an "autocrine drug resistance loop" is suppressed by melanocyte lineage signal(s), such as MITF. This resistance loop modulates drug response and could explain the unique sensitivity of melanomas to BRAF inhibition.Journal of Investigative Dermatology accepted article preview online, 19 March 2015. doi:10.1038/jid.2015.105.
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Erin Chen, Yiyin
(author)
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Kumar, Raj
(author)
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Taylor, Michael
(author)
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Jenny Njauw, Ching-Ni
(author)
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Miao, Benchun
(author)
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Frederick, Dennie T
(author)
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Wargo, Jennifer A
(author)
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Flaherty, Keith T
(author)
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Jönsson, Göran BLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-gjo
(author)
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Tsao, Hensin
(author)
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Bröstcancer-genetikSektion I
(creator_code:org_t)
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In:Journal of Investigative Dermatology: Elsevier BV135:7, s. 1863-18721523-17470022-202X
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Ji, Zhenyu
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Erin Chen, Yiyin
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Kumar, Raj
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Taylor, Michael
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Jenny Njauw, Chi ...
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Miao, Benchun
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Frederick, Denni ...
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Wargo, Jennifer ...
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Flaherty, Keith ...
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Jönsson, Göran B
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Tsao, Hensin
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Dermatology and ...
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Lund University