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Risk of solid subse...
Risk of solid subsequent malignant neoplasms after childhood Hodgkin lymphoma–identification of high-risk populations to guide surveillance : A report from the Late Effects Study Group
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- Holmqvist, Anna S. (author)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Chen, Yanjun (author)
- University of Alabama
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- Berano Teh, Jennifer (author)
- City of Hope National Medical Center
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- Sun, Canlan (author)
- City of Hope National Medical Center
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Birch, Jillian M. (author)
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- van den Bos, Cor (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Diller, Lisa R. (author)
- Dana-Farber Cancer Institute
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- Dilley, Kimberley (author)
- Northwestern University Feinberg School of Medicine
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- Ginsberg, Jill (author)
- Cochin Hospital
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- Martin, Laura T. (author)
- Ohio State University
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- Nagarajan, Rajaram (author)
- Cincinnati Children's Hospital Medical Center
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- Nathan, Paul C. (author)
- Hospital for Sick Children, Toronto
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- Neglia, Joseph P. (author)
- University of Minnesota Medical School
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- Terenziani, Monica (author)
- Istituto Nazionale dei Tumori
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- Tishler, David (author)
- University of Southern California
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- Meadows, Anna T. (author)
- The Children's Hospital of Philadelphia
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- Robison, Leslie L. (author)
- St Jude Children´s Research Hospital, Memphis
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- Oberlin, Odile (author)
- Institut Gustave Roussy
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- Bhatia, Smita (author)
- University of Alabama
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(creator_code:org_t)
- 2018-12-17
- 2019
- English.
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In: Cancer. - : Wiley. - 0008-543X .- 1097-0142. ; 125:8, s. 1373-1383
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Abstract
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- Background: Survivors of Hodgkin lymphoma (HL) in childhood have an increased risk of subsequent malignant neoplasms (SMNs). Herein, the authors extended the follow-up of a previously reported Late Effects Study Group cohort and identified patients at highest risk for SMNs to create evidence for risk-based screening recommendations. Methods: The standardized incidence ratio was calculated using rates from the Surveillance, Epidemiology, and End Results program as a reference. The risk of SMN was estimated using proportional subdistribution hazards regression. The cohort included 1136 patients who were diagnosed with HL before age 17 years between 1955 and 1986. The median length of follow-up was 26.6 years. Results: In 162 patients, a total of 196 solid SMNs (sSMNs) were identified. Compared with the general population, the cohort was found to be at a 14-fold increased risk of developing an sSMN (95% confidence interval, 12.0-fold to 16.3-fold). The cumulative incidence of any sSMN was 26.4% at 40 years after a diagnosis of HL. Risk factors for breast cancer among females were an HL diagnosis between ages 10 years and 16 years and receipt of chest radiotherapy. Males treated with chest radiotherapy at age <10 years were found to be at highest risk of developing lung cancer. Survivors of HL who were treated with abdominal/pelvic radiotherapy and high-dose alkylating agents were found to be at highest risk of developing colorectal cancer and females exposed to neck radiotherapy at age <10 years were at highest risk of thyroid cancer. By age 50 years, the cumulative incidence of breast, lung, colorectal, and thyroid cancer was 45.3%, 4.2%, 9.5%, and 17.3%, respectively, among those at highest risk. Conclusions: Survivors of childhood HL remain at an increased risk of developing sSMNs. In the current study, subgroups of survivors of HL at highest risk of specific sSMNs were identified, and evidence for screening provided.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- childhood
- Hodgkin lymphoma
- long-term follow-up
- screening recommendations
- subsequent malignant neoplasm (SMN)
Publication and Content Type
- art (subject category)
- ref (subject category)
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Holmqvist, Anna ...
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Chen, Yanjun
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Berano Teh, Jenn ...
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Sun, Canlan
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Birch, Jillian M ...
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van den Bos, Cor
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Diller, Lisa R.
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Dilley, Kimberle ...
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Ginsberg, Jill
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Martin, Laura T.
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Nagarajan, Rajar ...
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Nathan, Paul C.
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Neglia, Joseph P ...
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Terenziani, Moni ...
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Tishler, David
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Meadows, Anna T.
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Robison, Leslie ...
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Oberlin, Odile
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Bhatia, Smita
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Cancer
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Lund University