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  • Holmqvist, Anna S.Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital (författare)

Risk of solid subsequent malignant neoplasms after childhood Hodgkin lymphoma–identification of high-risk populations to guide surveillance : A report from the Late Effects Study Group

  • Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

  • 2018-12-17
  • Wiley,2019

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:153d9d0c-e760-40c2-a473-df4fd4645eca
  • https://lup.lub.lu.se/record/153d9d0c-e760-40c2-a473-df4fd4645ecaURI
  • https://doi.org/10.1002/cncr.31807DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Background: Survivors of Hodgkin lymphoma (HL) in childhood have an increased risk of subsequent malignant neoplasms (SMNs). Herein, the authors extended the follow-up of a previously reported Late Effects Study Group cohort and identified patients at highest risk for SMNs to create evidence for risk-based screening recommendations. Methods: The standardized incidence ratio was calculated using rates from the Surveillance, Epidemiology, and End Results program as a reference. The risk of SMN was estimated using proportional subdistribution hazards regression. The cohort included 1136 patients who were diagnosed with HL before age 17 years between 1955 and 1986. The median length of follow-up was 26.6 years. Results: In 162 patients, a total of 196 solid SMNs (sSMNs) were identified. Compared with the general population, the cohort was found to be at a 14-fold increased risk of developing an sSMN (95% confidence interval, 12.0-fold to 16.3-fold). The cumulative incidence of any sSMN was 26.4% at 40 years after a diagnosis of HL. Risk factors for breast cancer among females were an HL diagnosis between ages 10 years and 16 years and receipt of chest radiotherapy. Males treated with chest radiotherapy at age <10 years were found to be at highest risk of developing lung cancer. Survivors of HL who were treated with abdominal/pelvic radiotherapy and high-dose alkylating agents were found to be at highest risk of developing colorectal cancer and females exposed to neck radiotherapy at age <10 years were at highest risk of thyroid cancer. By age 50 years, the cumulative incidence of breast, lung, colorectal, and thyroid cancer was 45.3%, 4.2%, 9.5%, and 17.3%, respectively, among those at highest risk. Conclusions: Survivors of childhood HL remain at an increased risk of developing sSMNs. In the current study, subgroups of survivors of HL at highest risk of specific sSMNs were identified, and evidence for screening provided.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Chen, YanjunUniversity of Alabama (författare)
  • Berano Teh, JenniferCity of Hope National Medical Center (författare)
  • Sun, CanlanCity of Hope National Medical Center (författare)
  • Birch, Jillian M. (författare)
  • van den Bos, CorAcademic Medical Center of University of Amsterdam (AMC) (författare)
  • Diller, Lisa R.Dana-Farber Cancer Institute (författare)
  • Dilley, KimberleyNorthwestern University Feinberg School of Medicine (författare)
  • Ginsberg, JillCochin Hospital (författare)
  • Martin, Laura T.Ohio State University (författare)
  • Nagarajan, RajaramCincinnati Children's Hospital Medical Center (författare)
  • Nathan, Paul C.Hospital for Sick Children, Toronto (författare)
  • Neglia, Joseph P.University of Minnesota Medical School (författare)
  • Terenziani, MonicaIstituto Nazionale dei Tumori (författare)
  • Tishler, DavidUniversity of Southern California (författare)
  • Meadows, Anna T.The Children's Hospital of Philadelphia (författare)
  • Robison, Leslie L.St Jude Children´s Research Hospital, Memphis (författare)
  • Oberlin, OdileInstitut Gustave Roussy (författare)
  • Bhatia, SmitaUniversity of Alabama (författare)
  • Pediatrik, LundSektion V (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Cancer: Wiley125:8, s. 1373-13830008-543X1097-0142

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  • Cancer (Sök värdpublikationen i LIBRIS)

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