Mechanical ventilation in patients with cardiogenic pulmonary edema : a sub-analysis of the LUNG SAFE study

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Sökning: WFRF:(Bellani M.) > Mechanical ventilat...

Amado-Rodríguez, LauraCIBER Enfermedades Respiratorias (CIBERES),University of Oviedo,Asturias General Hospital (författare)

Mechanical ventilation in patients with cardiogenic pulmonary edema : a sub-analysis of the LUNG SAFE study

Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

2022-12-25
Springer Science and Business Media LLC,2022

Nummerbeteckningar

LIBRIS-ID:oai:lup.lub.lu.se:1558bed1-c4cb-4832-b3b3-86459b80ad75
https://lup.lub.lu.se/record/1558bed1-c4cb-4832-b3b3-86459b80ad75URI
https://doi.org/10.1186/s40560-022-00648-xDOI

Kompletterande språkuppgifter

Språk:engelska
Sammanfattning på:engelska

Ingår i deldatabas

SwePubSwePub

Klassifikation

Ämneskategori:art swepub-publicationtype
Ämneskategori:ref swepub-contenttype

Anmärkningar

Background: Patients with acute respiratory failure caused by cardiogenic pulmonary edema (CPE) may require mechanical ventilation that can cause further lung damage. Our aim was to determine the impact of ventilatory settings on CPE mortality. Methods: Patients from the LUNG SAFE cohort, a multicenter prospective cohort study of patients undergoing mechanical ventilation, were studied. Relationships between ventilatory parameters and outcomes (ICU discharge/hospital mortality) were assessed using latent mixture analysis and a marginal structural model. Results: From 4499 patients, 391 meeting CPE criteria (median age 70 [interquartile range 59–78], 40% female) were included. ICU and hospital mortality were 34% and 40%, respectively. ICU survivors were younger (67 [57–77] vs 74 [64–80] years, p < 0.001) and had lower driving (12 [8–16] vs 15 [11–17] cmH2O, p < 0.001), plateau (20 [15–23] vs 22 [19–26] cmH2O, p < 0.001) and peak (21 [17–27] vs 26 [20–32] cmH2O, p < 0.001) pressures. Latent mixture analysis of patients receiving invasive mechanical ventilation on ICU day 1 revealed a subgroup ventilated with high pressures with lower probability of being discharged alive from the ICU (hazard ratio [HR] 0.79 [95% confidence interval 0.60–1.05], p = 0.103) and increased hospital mortality (HR 1.65 [1.16–2.36], p = 0.005). In a marginal structural model, driving pressures in the first week (HR 1.12 [1.06–1.18], p < 0.001) and tidal volume after day 7 (HR 0.69 [0.52–0.93], p = 0.015) were related to survival. Conclusions: Higher airway pressures in invasively ventilated patients with CPE are related to mortality. These patients may be exposed to an increased risk of ventilator-induced lung injury. Trial registration Clinicaltrials.gov NCT02010073.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Lungmedicin och allergi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Respiratory Medicine and Allergy hsv//eng
Cardiogenic pulmonary edema
Driving pressure
Mechanical ventilation
Ventilator-induced lung injury

Biuppslag (personer, institutioner, konferenser, titlar ...)

Rodríguez-Garcia, RaquelCIBER Enfermedades Respiratorias (CIBERES),Asturias General Hospital (författare)
Bellani, GiacomoUniversity of Milano-Bicocca (författare)
Pham, TàiUniversity of Paris-Saclay (författare)
Fan, EddyMount Sinai Hospital of University of Toronto (författare)
Madotto, FabianaMaggiore Hospital Policlinico (författare)
Laffey, John G.Galway University Hospital (författare)
Albaiceta, Guillermo M.University of Oviedo,Asturias General Hospital,CIBER Enfermedades Respiratorias (CIBERES) (författare)
Kander, ThomasLund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk forskning inom anestesi och intensivvårdsmedicin,Forskargrupper vid Lunds universitet,Lärare vid läkarprogrammet,Avdelningen för läkarprogrammets kursadministration,Utbildningsenheten,Kansli M,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Research in Anaesthesia and Intensive Care Medicine,Lund University Research Groups,Teachers at the Medical Programme,Division of Course Administration for the Medical Programme,The Education Office,Faculty Office - BMC(Swepub:lu)med-tkn (creator_code:cre_t)
CIBER Enfermedades Respiratorias (CIBERES)University of Oviedo (creator_code:org_t)
LUNG SAFE Investigators

Sammanhörande titlar

Ingår i:Journal of Intensive Care: Springer Science and Business Media LLC10:12052-0492

Internetlänk

Hitta via bibliotek

Journal of Intensive Care (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Amado-Rodríguez, ...; Rodríguez-Garcia ...; Bellani, Giacomo; Pham, Tài; Fan, Eddy; Madotto, Fabiana; visa fler...; Laffey, John G.; Albaiceta, Guill ...; Kander, Thomas; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Lungmedicin och ...

Artiklar i publikationen: Journal of Inten ...

Av lärosätet: Lunds universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se