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Comorbidities in pe...
Comorbidities in people with hand OA and their associations with pain severity and sensitization : Data from the longitudinal Nor-Hand study
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- Mulrooney, Elisabeth (författare)
- Diakonhjemmet Hospital,University of Oslo
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- Neogi, Tuhina (författare)
- Boston University
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- Dagfinrud, Hanne (författare)
- Diakonhjemmet Hospital,University of Oslo
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- Hammer, Hilde Berner (författare)
- Diakonhjemmet Hospital,University of Oslo
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- Pettersen, Pernille Steen (författare)
- Diakonhjemmet Hospital
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- Gløersen, Marthe (författare)
- Diakonhjemmet Hospital,University of Oslo
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- Kvien, Tore K. (författare)
- University of Oslo,Diakonhjemmet Hospital
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- Magnusson, Karin (författare)
- Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,LU Profile Area: Proactive Ageing,Lund University Profile areas
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- Haugen, Ida K. (författare)
- Diakonhjemmet Hospital,University of Oslo
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Osteoarthritis and Cartilage Open. - 2665-9131. ; 5:3
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective: To determine whether the comorbidity burden and co-existing comorbidities are cross-sectionally and/or longitudinally associated with pain and pain sensitization in a cohort study of people with hand OA. Design: We examined whether comorbidity burden and individual comorbidities based on the self-administered Comorbidity Index (range: 0–42) at baseline were associated with pain outcomes at baseline and 3 years follow-up. Pain outcomes included hand and overall bodily pain (range: 0–10) as well as pressure pain thresholds at the tibialis anterior muscle (kg/cm2) and temporal summation (distal radioulnar joint) as measures of central pain sensitization. We performed linear regression analyses adjusted for age, sex, body mass index, physical exercise and education. Results: We included 300 and 196 participants in cross-sectional and longitudinal analyses, respectively. Using baseline data, the burden of comorbidities was associated with greater pain in hands (beta = 0.61, 95% CI 0.37, 0.85) and overall body (beta = 0.60, 95% CI 0.37, 0.87). Similar strength of associations was found between comorbidity burden (baseline) and follow-up pain. Among the individual comorbidities, back pain and depression were associated with nearly one unit higher pain score in hands and overall body at both baseline and follow-up. Only back pain was related to lower pressure pain thresholds at follow up (beta = −0.24, 95% CI −0.50, −0.001). Conclusion: People with hand OA and greater comorbidity burden, co-existing back pain or depression reported greater pain severity than their counterparts, also 3 years later. These results acknowledge the relevance of accounting for comorbidities in the pain experience in people with hand OA.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- Comorbidity
- Hand osteoarthritis
- Osteoarthritis
- Pain
- Pain sensitization
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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