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Use of flutemetamol...
Use of flutemetamol F18-labeled positron emission tomography and other biomarkers to assess risk of clinical progression in patients with amnestic mild cognitive impairment
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- Wolk, David A. (author)
- University of Pennsylvania
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- Sadowsky, Carl (author)
- Nova Southeastern University
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- Safirstein, Beth (author)
- MD Clinical, Hallandale Beach
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- Rinne, Juha O. (author)
- Turku University Hospital,University of Turku
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- Duara, Ranjan (author)
- Mount Sinai Medical Center, Miami Beach
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- Perry, Richard (author)
- Charing Cross Hospital,Imperial College London
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- Agronin, Marc (author)
- Miami Jewish Health Systems
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- Gamez, Jose (author)
- Galiz Research
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- Shi, Jiong (author)
- St. Joseph's Hospital and Medical Center
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- Ivanoiu, Adrian (author)
- Saint-Luc University Hospital
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- Minthon, Lennart (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Walker, Zuzana (author)
- Essex Partnership University Foundation Trust Essex,University College London
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- Hasselbalch, Steen (author)
- University of Copenhagen,Copenhagen University Hospital
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- Holmes, Clive (author)
- Moorgreen Hospital,University of Southampton
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- Sabbagh, Marwan (author)
- Banner Sun Health Research Institute
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- Albert, Marilyn (author)
- Johns Hopkins University
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- Fleisher, Adam (author)
- Banner Alzheimer's Institute,Eli Lilly and Company
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- Loughlin, Paul (author)
- Princess Margaret Hospital, Windsor
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- Triau, Eric (author)
- No affiliation available (private)
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- Frey, Kirk (author)
- University of Michigan
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- Høgh, Peter (author)
- Copenhagen University Hospital
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- Bozoki, Andrea (author)
- Michigan State University
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- Bullock, Roger (author)
- Kingshill Research Centre
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- Salmon, Eric (author)
- University of Liège
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- Farrar, Gillian (author)
- GE Healthcare, UK
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- Buckley, Christopher J. (author)
- GE Healthcare, UK
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- Zanette, Michelle (author)
- GE Healthcare, UK
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- Sherwin, Paul F. (author)
- GE Healthcare, UK
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- Cherubini, Andrea (author)
- CNR Institute of Molecular Bioimaging and Physiology, Italy (IBFM-CNR)
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- Inglis, Fraser (author)
- Glasgow Memory Clinic Ltd.
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(creator_code:org_t)
- American Medical Association (AMA), 2018
- 2018
- English 10 s.
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In: JAMA Neurology. - : American Medical Association (AMA). - 2168-6149. ; 75:9, s. 1114-1123
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http://dx.doi.org/10...
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https://jamanetwork....
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Abstract
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- Importance: Patients with amnestic mild cognitive impairment (aMCI) may progress to clinical Alzheimer disease (AD), remain stable, or revert to normal. Earlier progression to AD among patients who were β-amyloid positive vs those who were β-amyloid negative has been previously observed. Current research now accepts that a combination of biomarkers could provide greater refinement in the assessment of risk for clinical progression. Objective: To evaluate the ability of flutemetamol F 18 and other biomarkers to assess the risk of progression from aMCI to probable AD. Design, Setting, and Participants: In this multicenter cohort study, from November 11, 2009, to January 16, 2014, patients with aMCI underwent positron emission tomography (PET) at baseline followed by local clinical assessments every 6 months for up to 3 years. Patients with aMCI (365 screened; 232 were eligible) were recruited from 28 clinical centers in Europe and the United States. Physicians remained strictly blinded to the results of PET, and the standard of truth was an independent clinical adjudication committee that confirmed or refuted local assessments. Flutemetamol F 18-labeled PET scans were read centrally as either negative or positive by 5 blinded readers with no knowledge of clinical status. Statistical analysis was conducted from February 19, 2014, to January 26, 2018. Interventions: Flutemetamol F 18-labeled PET at baseline followed by up to 6 clinical visits every 6 months, as well as magnetic resonance imaging and multiple cognitive measures. Main Outcomes and Measures: Time from PET to probable AD or last follow-upwas plotted as a Kaplan-Meier survival curve; PET scan results, age, hippocampal volume, and aMCI stage were entered into Cox proportional hazards logistic regression analyses to identify variables associated with progression to probable AD. Results: Of 232 patients with aMCI (118 women and 114 men; mean [SD] age, 71.1 [8.6] years), 98 (42.2%) had positive results detected on PET scan. By 36 months, the rates of progression to probable AD were 36.2% overall (81 of 224 patients), 53.6%(52 of 97) for patients with positive results detected on PET scan, and 22.8% (29 of 127) for patients with negative results detected on PET scan. Hazard ratios for association with progression were 2.51 (95% CI, 1.57-3.99; P < .001) for a positive β-amyloid scan alone (primary outcome measure), 5.60 (95%CI, 3.14-9.98; P < .001) with additional low hippocampal volume, and 8.45 (95%CI, 4.40-16.24; P < .001) when poorer cognitive status was added to the model. Conclusions and Relevance: A combination of positive results of flutemetamol F 18-labeled PET, low hippocampal volume, and cognitive status corresponded with a high probability of risk of progression from aMCI to probable AD within 36 months.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Wolk, David A.
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Sadowsky, Carl
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Safirstein, Beth
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Rinne, Juha O.
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Duara, Ranjan
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Perry, Richard
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show more...
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Agronin, Marc
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Gamez, Jose
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Shi, Jiong
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Ivanoiu, Adrian
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Minthon, Lennart
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Walker, Zuzana
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Hasselbalch, Ste ...
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Holmes, Clive
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Sabbagh, Marwan
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Albert, Marilyn
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Fleisher, Adam
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Loughlin, Paul
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Triau, Eric
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Frey, Kirk
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Høgh, Peter
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Bozoki, Andrea
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Bullock, Roger
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Salmon, Eric
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Farrar, Gillian
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Buckley, Christo ...
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Zanette, Michell ...
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Sherwin, Paul F.
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Cherubini, Andre ...
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Inglis, Fraser
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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JAMA Neurology
- By the university
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Lund University