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Neuropsychological ...
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Dominguez Perez, SophiaUniversity of Connecticut,University of Pennsylvania
(author)
Neuropsychological and Neuroanatomical Features of Patients with Behavioral/Dysexecutive Variant Alzheimer's Disease (AD) : A Comparison to Behavioral Variant Frontotemporal Dementia and Amnestic AD Groups
- Article/chapterEnglish2022
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LIBRIS-ID:oai:lup.lub.lu.se:15827055-3461-44c7-a0ac-1a4f70e40f3e
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https://lup.lub.lu.se/record/15827055-3461-44c7-a0ac-1a4f70e40f3eURI
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https://doi.org/10.3233/JAD-215728DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Background: An understudied variant of Alzheimer's disease (AD), the behavioral/dysexecutive variant of AD (bvAD), is associated with progressive personality, behavior, and/or executive dysfunction and frontal atrophy. Objective: This study characterizes the neuropsychological and neuroanatomical features associated with bvAD by comparing it to behavioral variant frontotemporal dementia (bvFTD), amnestic AD (aAD), and subjects with normal cognition. Methods: Subjects included 16 bvAD, 67 bvFTD, 18 aAD patients, and 26 healthy controls. Neuropsychological assessment and MRI data were compared between these groups. Results: Compared to bvFTD, bvAD showed more significant visuospatial impairments (Rey Figure copy and recall), more irritability (Neuropsychological Inventory), and equivalent verbal memory (Philadelphia Verbal Learning Test). Compared to aAD, bvAD indicated more executive dysfunction (F-letter fluency) and better visuospatial performance. Neuroimaging analysis found that bvAD showed cortical thinning relative to bvFTD posteriorly in left temporal-occipital regions; bvFTD had cortical thinning relative to bvAD in left inferior frontal cortex. bvAD had cortical thinning relative to aAD in prefrontal and anterior temporal regions. All patient groups had lower volumes than controls in both anterior and posterior hippocampus. However, bvAD patients had higher average volume than aAD patients in posterior hippocampus and higher volume than bvFTD patients in anterior hippocampus after adjustment for age and intracranial volume. Conclusion: Findings demonstrated that underlying pathology mediates disease presentation in bvAD and bvFTD.
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Phillips, Jeffrey S.University of Pennsylvania
(author)
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Norise, CatherineUniversity of Pennsylvania
(author)
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Kinney, Nikolas G.University of Pennsylvania
(author)
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Vaddi, PreranaUniversity of Pennsylvania
(author)
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Halpin, AmyUniversity of Maine,University of Pennsylvania
(author)
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Rascovsky, KatyaUniversity of Pennsylvania
(author)
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Irwin, David J.University of Pennsylvania
(author)
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McMillan, Corey T.University of Pennsylvania
(author)
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Xie, LongHospital of the University of Pennsylvania,University of Pennsylvania
(author)
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Wisse, Laura E.M.Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,University of Pennsylvania,Hospital of the University of Pennsylvania(Swepub:lu)la3343wi
(author)
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Yushkevich, Paul A.Hospital of the University of Pennsylvania,University of Pennsylvania
(author)
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Kallogjeri, DorinaWashington University in St. Louis
(author)
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Grossman, MurrayUniversity of Pennsylvania
(author)
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Cousins, Katheryn A.Q.University of Pennsylvania
(author)
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University of ConnecticutUniversity of Pennsylvania
(creator_code:org_t)
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In:Journal of Alzheimer's Disease89:2, s. 641-6581387-2877
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Rascovsky, Katya
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