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Sökning: onr:"swepub:oai:lup.lub.lu.se:160bc376-f64e-4491-aba6-f73cd52bed5b" > Predictive Models f...

  • Lawlor, AilbheKing's College London (författare)

Predictive Models for Assessing Patients’ Response to Treatment in Metastatic Prostate Cancer : A Systematic Review

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • 2024
  • 10 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:160bc376-f64e-4491-aba6-f73cd52bed5b
  • https://lup.lub.lu.se/record/160bc376-f64e-4491-aba6-f73cd52bed5bURI
  • https://doi.org/10.1016/j.euros.2024.03.012DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:for swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Background and objective: The treatment landscape of metastatic prostate cancer (mPCa) has evolved significantly over the past two decades. Despite this, the optimal therapy for patients with mPCa has not been determined. This systematic review identifies available predictive models that assess mPCa patients’ response to treatment. Methods: We critically reviewed MEDLINE and CENTRAL in December 2022 according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement. Only quantitative studies in English were included with no time restrictions. The quality of the included studies was assessed using the PROBAST tool. Data were extracted following the Checklist for Critical Appraisal and Data Extraction for Systematic Reviews criteria. Key findings and limitations: The search identified 616 citations, of which 15 studies were included in our review. Nine of the included studies were validated internally or externally. Only one study had a low risk of bias and a low risk concerning applicability. Many studies failed to detail model performance adequately, resulting in a high risk of bias. Where reported, the models indicated good or excellent performance. Conclusions and clinical implications: Most of the identified predictive models require additional evaluation and validation in properly designed studies before these can be implemented in clinical practice to assist with treatment decision-making for men with mPCa. Patient summary: In this review, we evaluate studies that predict which treatments will work best for which metastatic prostate cancer patients. We found that existing studies need further improvement before these can be used by health care professionals.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Lin, CarolErasmus University Medical Center (författare)
  • Gómez Rivas, JuanHospital Clinico San Carlos de Madrid (författare)
  • Ibáñez, LauraHospital Clinico San Carlos de Madrid (författare)
  • Abad López, PabloUniversity Hospital La Paz (författare)
  • Willemse, Peter PaulUniversity Medical Center Utrecht (författare)
  • Imran Omar, MuhammadUniversity of Aberdeen (författare)
  • Remmers, SebastiaanErasmus University Medical Center (författare)
  • Cornford, PhilipUniversity of Liverpool (författare)
  • Rajwa, PawelMedical University of Silesia (författare)
  • Nicoletti, RossellaUniversity of Florence,Chinese University of Hong Kong (författare)
  • Gandaglia, GiorgioNortheastern University,San Raffaele Hospital (författare)
  • Yuen-Chun Teoh, JeremyChinese University of Hong Kong (författare)
  • Moreno Sierra, JesúsHospital Clinico San Carlos de Madrid (författare)
  • Golozar, AsiehOdysseus Data Services,Northeastern University (författare)
  • Bjartell, AndersLund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Urological cancer, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)kir-abj (författare)
  • Evans-Axelsson, Susan (författare)
  • N'Dow, James (författare)
  • Zong, JihongBayer Corporation, USA (författare)
  • Ribal, Maria J. (författare)
  • Roobol, Monique J.Erasmus University Medical Center (författare)
  • Van Hemelrijck, MiekeKing's College London (författare)
  • Beyer, KatharinaErasmus University Medical Center (författare)
  • King's College LondonErasmus University Medical Center (creator_code:org_t)
  • The PIONEER Consortium

Sammanhörande titlar

  • Ingår i:European Urology Open Science63, s. 126-1352666-1691

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