Sökning: L773:1550 6606 OR L773:0022 1767
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New loci regulating...
New loci regulating rat myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis
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- Becanovic, K (författare)
- Karolinska Institutet
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Wallstrom, E (författare)
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Kornek, B (författare)
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visa fler...
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- Glaser, A (författare)
- Karolinska Institutet
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Broman, KW (författare)
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- Dahlman, I (författare)
- Karolinska Institutet
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- Olofsson, Peter (författare)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups
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- Holmdahl, Rikard (författare)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups
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Luthman, H (författare)
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Lassmann, H (författare)
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- Olsson, T (författare)
- Karolinska Institutet
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(creator_code:org_t)
- The American Association of Immunologists, 2003
- 2003
- Engelska.
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Ingår i: Journal of Immunology. - : The American Association of Immunologists. - 1550-6606 .- 0022-1767. ; 170:2, s. 1062-1069
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http://www.jimmunol....
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https://doi.org/10.4...
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Abstract
Ämnesord
Stäng
- Myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis (EAE) is an inflammatory disease in rats that closely mimics many clinical and histopathological aspects of multiple sclerosis. Non-MHC quantitative trait loci regulating myelin oligodendrocyte glycoprotein-induced EAE have previously been identified in the EAE-permissive strain, DA, on rat chromosomes 4,10,15, and 18. To find any additional gene loci in another well-known EAE-permissive strain and thereby to assess any genetic heterogeneity in the regulation of the disease, we have performed a genome-wide linkage analysis in a reciprocal (LEW.1AV1 x PVG.1AV1) male/female F-2 population (n = 185). We examined reciprocal crosses, but no parent-of-origin effect was detected. The parental rat strains share the RT1(av1) MHC haplotype; thus, non-MHC genes control differences in EAE susceptibility. We identified Eae(16) on chromosome 8 and Eae17 on chromosome 13, significantly linked to EAE phenotypes. Two loci, on chromosomes 1 and 17, respectively showed suggestive linkage to clinical and histopathological EAE phenotypes. Eae16 and Eae17 differ from those found in previously studied strain combinations, thus demonstrating genetic heterogeneity of EAE. Furthermore, we detected a locus-specific parent-of-origin effect with suggestive linkage in Eae17. Further genetic and functional dissection of these loci may disclose critical disease-regulating molecular mechanisms.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
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Becanovic, K
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Wallstrom, E
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Kornek, B
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Glaser, A
-
Broman, KW
-
Dahlman, I
-
visa fler...
-
Olofsson, Peter
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Holmdahl, Rikard
-
Luthman, H
-
Lassmann, H
-
Olsson, T
-
visa färre...
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- Av lärosätet
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Lunds universitet
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Karolinska Institutet