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Risk factors for kn...
Risk factors for knee osteoarthritis after traumatic knee injury : A systematic review and meta-analysis of randomised controlled trials and cohort studies for the OPTIKNEE Consensus
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- Whittaker, Jackie L. (författare)
- University of British Columbia
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- Losciale, Justin M. (författare)
- University of British Columbia
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- Juhl, Carsten B. (författare)
- Copenhagen University Hospital,University of Southern Denmark
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- Thorlund, Jonas Bloch (författare)
- University of Southern Denmark
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- Lundberg, Matilde (författare)
- University of Southern Denmark
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- Truong, Linda K. (författare)
- University of British Columbia
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- Miciak, Maxi (författare)
- University of Alberta
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- Van Meer, Belle Lore (författare)
- Erasmus University Medical Center
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- Culvenor, Adam G. (författare)
- La Trobe University
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- Crossley, Kay M. (författare)
- La Trobe University
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- Roos, Ewa M. (författare)
- University of Southern Denmark
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- Lohmander, Stefan (författare)
- Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund OsteoArthritis Division - Nedbrytning av ledbrosk: en biologisk process som leder till artros,Forskargrupper vid Lunds universitet,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund OsteoArthritis Division - Molecular marker research group,Lund University Research Groups
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- Van Middelkoop, Marienke (författare)
- Erasmus University Medical Center
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(creator_code:org_t)
- 2022-09-02
- 2022
- Engelska.
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Ingår i: British journal of sports medicine. - : BMJ. - 0306-3674 .- 1473-0480. ; 56:24, s. 1406-1421
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Abstract
Ämnesord
Stäng
- Objective: To identify and quantify potential risk factors for osteoarthritis (OA) following traumatic knee injury. Design: Systematic review and meta-analyses that estimated the odds of OA for individual risk factors assessed in more than four studies using random-effects models. Remaining risk factors underwent semiquantitative synthesis. The modified GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach for prognostic factors guided the assessment. Data sources: MEDLINE, EMBASE, CENTRAL, SPORTDiscus, CINAHL searched from inception to 2009-2021. Eligibility: Randomised controlled trials and cohort studies assessing risk factors for symptomatic or structural OA in persons with a traumatic knee injury, mean injury age ≤30 years and minimum 2-year follow-up. Results: Across 66 included studies, 81 unique potential risk factors were identified. High risk of bias due to attrition or confounding was present in 64% and 49% of studies, respectively. Ten risk factors for structural OA underwent meta-analysis (sex, rehabilitation for anterior cruciate ligament (ACL) tear, ACL reconstruction (ACLR), ACLR age, ACLR body mass index, ACLR graft source, ACLR graft augmentation, ACLR+cartilage injury, ACLR+partial meniscectomy, ACLR+total medial meniscectomy). Very-low certainty evidence suggests increased odds of structural OA related to ACLR+cartilage injury (OR=2.31; 95% CI 1.35 to 3.94), ACLR+partial meniscectomy (OR=1.87; 1.45 to 2.42) and ACLR+total medial meniscectomy (OR=3.14; 2.20 to 4.48). Semiquantitative syntheses identified moderate-certainty evidence that cruciate ligament, collateral ligament, meniscal, chondral, patellar/tibiofemoral dislocation, fracture and multistructure injuries increase the odds of symptomatic OA. Conclusion: Moderate-certainty evidence suggests that various single and multistructure knee injuries (beyond ACL tears) increase the odds of symptomatic OA. Risk factor heterogeneity, high risk of bias, and inconsistency in risk factors and OA definition make identifying treatment targets for preventing post-traumatic knee OA challenging.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
Nyckelord
- anterior cruciate ligament
- meniscus
- osteoarthritis
- risk factor
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Whittaker, Jacki ...
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Losciale, Justin ...
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Juhl, Carsten B.
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Thorlund, Jonas ...
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Lundberg, Matild ...
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Truong, Linda K.
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Miciak, Maxi
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Van Meer, Belle ...
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Culvenor, Adam G ...
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Crossley, Kay M.
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Roos, Ewa M.
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Lohmander, Stefa ...
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Van Middelkoop, ...
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