Inflammatory markers and mortality in critical lower limb ischemia

• In atherosclerotic vascular disease, endothelial dysfunction is induced by risk factors such as arterial hypertension, hypercholesterolemia, and tobacco use. In fl ammatory mechanisms and in fl ammatory cytokines play important roles in all of these mechanisms, and the different steps in atherogenesis involve cytokines as in fl ammatory promoters, stimulating the expression of proatherogenic genes in endothelial cells [1, 2]. Important cytokines are, for example, tumor necrosis factor a [3], neopterin [4], and interleukin-6 [3, 5]. Expression of the immune mediator CD40 ligand is increased in atherogenesis [6, 7], and prostaglandin-like isoprostanes [8, 9] are markers of lipid peroxidation and believed to contribute to atherosclerosis and thrombosis [10].

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

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