Hormonal factors and pancreatic cancer risk in women : The Malmö Diet and Cancer Study

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Andersson, GustavLund University,Lunds universitet,Personlig patologi och cancerbehandling,Forskargrupper vid Lunds universitet,Personalized Pathology & Cancer Therapy,Lund University Research Groups (author)

Hormonal factors and pancreatic cancer risk in women : The Malmö Diet and Cancer Study

Article/chapterEnglish2018

Publisher, publication year, extent ...

2018-02-21
Wiley,2018
11 s.

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LIBRIS-ID:oai:lup.lub.lu.se:18781fc1-86a6-4dfe-a299-8f46edee3b0a
https://lup.lub.lu.se/record/18781fc1-86a6-4dfe-a299-8f46edee3b0aURI
https://doi.org/10.1002/ijc.31302DOI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

Notes

The incidence of pancreatic cancer is leveling between sexes. Smoking, high age and heredity are established risk factors, but evidence regarding the influence of hormonal factors is unclear. In this study, we investigated the associations of reproductive factors, use of oral contraceptives (OC) and hormone replacement therapy (HRT) with pancreatic cancer risk in the Malmö Diet and Cancer Study, a prospective, population-based cohort encompassing 17,035 women. Up until 31 December 2015, 110 women were identified with incident pancreatic cancer through the Swedish Cancer Registry. Higher age at menarche was significantly associated with pancreatic cancer risk (age-adjusted [hazard ratio] HR = 1.17; 95% confidence interval [CI] 1.04–1.32, and fully adjusted HR = 1.17; 95% CI 1.04–1.32). Ever use of OC was not significantly associated with pancreatic cancer risk but ever use of HRT was significantly associated with a decreased risk of pancreatic cancer (age-adjusted HR = 0.47, 95% CI 0.23–0.97, and fully adjusted HR = 0.48, 95% CI 0.23–1.00), in particular use of estrogen-only regimen (age-adjusted HR = 0.21; 95% CI 0.05–0.87 and fully adjusted HR = 0.22; 95% CI 0.05–0.90). Age at menopause or first childbirth, parity and breastfeeding history were not significantly associated with pancreatic cancer risk. Collectively, these findings suggest a protective role of female hormones against pancreatic cancer. Further studies are needed, and potential modifying genetic factors and indirect hazardous effects of smoking should also be considered.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
hormone replacement therapy
oral contraceptives
pancreatic cancer risk
reproductive factors

Added entries (persons, corporate bodies, meetings, titles ...)

Borgquist, SigneLund University,Lunds universitet,Bröstcancer - prevention & intervention,Forskargrupper vid Lunds universitet,Breast cancer prevention & intervention,Lund University Research Groups,Skåne University Hospital(Swepub:lu)ront-sbo (author)
Jirström, KarinLund University,Lunds universitet,Personlig patologi och cancerbehandling,Forskargrupper vid Lunds universitet,Personalized Pathology & Cancer Therapy,Lund University Research Groups(Swepub:lu)pat-kji (author)
Personlig patologi och cancerbehandlingForskargrupper vid Lunds universitet (creator_code:org_t)

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In:International Journal of Cancer: Wiley143:1, s. 52-620020-7136

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