Search: (WFRF:(Johnson Jessica S)) pers:(Montgomery Grant W.) >
Large-Scale Gene-Ce...
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Asselbergs, Folkert W.
(author)
Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci
- Article/chapterEnglish2012
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LIBRIS-ID:oai:lup.lub.lu.se:19739b80-cdd4-4db7-b175-028cfda89d8f
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https://lup.lub.lu.se/record/3244000URI
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https://doi.org/10.1016/j.ajhg.2012.08.032DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Genome-wide association studies (GWASs) have identified many SNPs underlying variations in plasma-lipid levels. We explore whether additional loci associated with plasma-lipid phenotypes, such as high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TGs), can be identified by a dense gene-centric approach. Our meta-analysis of 32 studies in 66,240 individuals of European ancestry was based on the custom similar to 50,000 SNP genotyping array (the ITMAT-Broad-CARe array) covering similar to 2,000 candidate genes. SNP-lipid associations were replicated either in a cohort comprising an additional 24,736 samples or within the Global Lipid Genetic Consortium. We identified four, six, ten, and four unreported SNPs in established lipid genes for HDL-C, LDL-C, TC, and TGs, respectively. We also identified several lipid-related SNPs in previously unreported genes: DGAT2, HCAR2, GPIHBP1, PPARG, and FTO for HDL-C; SOCS3, APOH, SPTY2D1, BRCA2, and VLDLR for LDL-C; SOCS3, UGT1A1, BRCA2, UBE3B, FCGR2A, CHUK, and INSIG2 for TC; and SERPINF2, C4B, GCK, GATA4, INSR, and LPAL2 for TGs. The proportion of explained phenotypic variance in the subset of studies providing individual-level data was 9.9% for HDL-C, 9.5% for LDL-C, 10.3% for TC, and 8.0% for TGs. This large meta-analysis of lipid phenotypes with the use of a dense gene-centric approach identified multiple SNPs not previously described in established lipid genes and several previously unknown loci. The explained phenotypic variance from this approach was comparable to that from a meta-analysis of GWAS data, suggesting that a focused genotyping approach can further increase the understanding of heritability of plasma lipids.
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Guo, Yiran
(author)
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van Iperen, Erik P. A.
(author)
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Sivapalaratnam, Suthesh
(author)
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Tragante, Vinicius
(author)
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Lanktree, Matthew B.
(author)
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Lange, Leslie A.
(author)
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Almoguera, Berta
(author)
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Appelman, Yolande E.
(author)
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Barnard, John
(author)
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Baumert, Jens
(author)
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Beitelshees, Amber L.
(author)
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Bhangale, Tushar R.
(author)
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Chen, Yii-Der Ida
(author)
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Gaunt, Tom R.
(author)
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Gong, Yan
(author)
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Hopewell, Jemma C.
(author)
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Johnson, Toby
(author)
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Kleber, Marcus E.
(author)
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Langaee, Taimour Y.
(author)
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Li, Mingyao
(author)
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Li, Yun R.
(author)
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Liu, Kiang
(author)
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McDonough, Caitrin W.
(author)
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Meijs, Matthijs El.
(author)
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Middelberg, Rita P. S.
(author)
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Musunuru, Kiran
(author)
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Nelson, Christopher P.
(author)
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O'Connell, Jeffery R.
(author)
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Padmanabhan, Sandosh
(author)
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Pankow, James S.
(author)
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Pankratz, Nathan
(author)
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Rafelt, Suzanne
(author)
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Rajagopalan, Ramakrishnan
(author)
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Romaine, Simon P. R.
(author)
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Schork, Nicholas J.
(author)
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Shaffer, Jonathan
(author)
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Shen, Haiqing
(author)
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Smith, Erin N.
(author)
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Tischfield, Sam E.
(author)
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van der Most, Peter J.
(author)
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van Vliet-Ostaptchouk, Jana V.
(author)
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Verweij, Niek
(author)
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Volcik, Kelly A.
(author)
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Zhang, Li
(author)
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Bailey, Kent R.
(author)
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Bailey, Kristian M.
(author)
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Bauer, Florianne
(author)
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Boer, Jolanda M. A.
(author)
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Braund, Peter S.
(author)
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Burt, Amber
(author)
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Burton, Paul R.
(author)
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Buxbaum, Sarah G.
(author)
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Chen, Wei
(author)
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Cooper-DeHoff, Rhonda M.
(author)
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Cupples, L. Adrienne
(author)
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deJong, Jonas S.
(author)
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Delles, Christian
(author)
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Duggan, David
(author)
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Fornage, Myriam
(author)
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Furlong, Clement E.
(author)
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Glazer, Nicole
(author)
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Gums, John G.
(author)
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Hastie, Claire
(author)
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Holmes, Michael V.
(author)
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Illig, Thomas
(author)
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Kirkland, Susan A.
(author)
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Kivimaki, Mika
(author)
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Klein, Ronald
(author)
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Klein, Barbara E.
(author)
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Kooperberg, Charles
(author)
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Kottke-Marchant, Kandice
(author)
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Kumari, Meena
(author)
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LaCroix, Andrea Z.
(author)
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Mallela, Laya
(author)
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Murugesan, Gurunathan
(author)
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Ordovas, Jose
(author)
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Ouwehand, Willem H.
(author)
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Post, Wendy S.
(author)
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Saxena, Richa
(author)
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Scharnagl, Hubert
(author)
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Schreiner, Pamela J.
(author)
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Shah, Tina
(author)
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Shields, Denis C.
(author)
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Shimbo, Daichi
(author)
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Srinivasan, Sathanur R.
(author)
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Stolk, Ronald P.
(author)
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Swerdlow, Daniel I.
(author)
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Taylor Jr, Herman A.
(author)
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Topo, Eric J.
(author)
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Toskala, Elina
(author)
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van Pelt, Joost L.
(author)
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van Setten, Jessica
(author)
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Yusuf, Salim
(author)
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Whittaker, John C.
(author)
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Zwinderman, A. H.
(author)
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Anand, Sonia S.
(author)
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Balmforth, Anthony J.
(author)
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Berenson, Gerald S.
(author)
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Bezzina, Connie R.
(author)
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Boehm, Bernhard O.
(author)
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Boerwinkle, Eric
(author)
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Casas, Juan P.
(author)
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Caulfield, Mark J.
(author)
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Clarke, Robert
(author)
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Connell, John M.
(author)
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Cruickshanks, Karen J.
(author)
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Davidson, Karina W.
(author)
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Day, Ian N. M.
(author)
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de Bakker, Paul I. W.
(author)
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Doevendans, Pieter A.
(author)
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Dominiczak, Anna E.
(author)
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Hall, Alistair S.
(author)
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Hartman, Catharina A.
(author)
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Hengstenberg, Christian
(author)
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Hillege, Hans L.
(author)
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Hofker, Marten H.
(author)
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Humphries, Steve E.
(author)
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Jarvik, Gail P.
(author)
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Johnson, Julie A.
(author)
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Kaess, Bernhard M.
(author)
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Kathiresan, Sekar
(author)
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Koenig, Wolfgang
(author)
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Lawlor, Debbie A.
(author)
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Maerz, Winfried
(author)
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Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome
(author)
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Mitchell, Braxton D.
(author)
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Montgomery, Grant W.
(author)
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Munroe, Patricia B.
(author)
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Murray, Sarah S.
(author)
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Newhouse, Stephen J.
(author)
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Onland-Moret, N. Charlotte
(author)
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Poulter, Neil
(author)
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Psaty, Bruce
(author)
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Redline, Susan
(author)
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Rich, Stephen S.
(author)
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Rotter, Jerome I.
(author)
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Schunkert, Heribert
(author)
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Sever, Peter
(author)
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Shuldiner, Alan R.
(author)
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Silverstein, Roy L.
(author)
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Stanton, Alice
(author)
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Thorand, Barbara
(author)
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Trip, Mieke D.
(author)
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Tsai, Michael Y.
(author)
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van der Harst, Pim
(author)
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van der Schoot, Ellen
(author)
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van der Schouw, Yvonne T.
(author)
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Verschuren, W. M. Monique
(author)
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Watkins, Hugh
(author)
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Wilde, Arthur A. M.
(author)
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Wolffenbuttel, Bruce H. R.
(author)
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Whitfield, John B.
(author)
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Hovingh, G. Kees
(author)
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Ballantyne, Christie M.
(author)
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Wijmenga, Cisca
(author)
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Reilly, Muredach P.
(author)
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Martin, Nicholas G.
(author)
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Wilson, James G.
(author)
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Rader, Daniel J.
(author)
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Samani, Nilesh J.
(author)
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Reiner, Alex P.
(author)
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Hegele, Robert A.
(author)
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Kastelein, John J. P.
(author)
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Hingorani, Aroon D.
(author)
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Talmud, Philippa J.
(author)
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Hakonarson, Hakon
(author)
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Elbers, Clara C.
(author)
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Keating, Brendan J.
(author)
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Drenos, Fotios
(author)
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Kardiovaskulär forskning - hypertoniForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:American Journal of Human Genetics: Elsevier BV91:5, s. 823-8380002-9297
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Asselbergs, Folk ...
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Guo, Yiran
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van Iperen, Erik ...
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Sivapalaratnam, ...
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Tragante, Vinici ...
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Lanktree, Matthe ...
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show more...
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Lange, Leslie A.
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Almoguera, Berta
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Appelman, Yoland ...
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Barnard, John
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Baumert, Jens
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Beitelshees, Amb ...
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Bhangale, Tushar ...
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Chen, Yii-Der Id ...
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Gaunt, Tom R.
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Gong, Yan
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Hopewell, Jemma ...
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Johnson, Toby
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Kleber, Marcus E ...
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Langaee, Taimour ...
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Li, Mingyao
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Li, Yun R.
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Liu, Kiang
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McDonough, Caitr ...
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Meijs, Matthijs ...
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Middelberg, Rita ...
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Musunuru, Kiran
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Nelson, Christop ...
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O'Connell, Jeffe ...
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Padmanabhan, San ...
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Pankow, James S.
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Pankratz, Nathan
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Rafelt, Suzanne
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Rajagopalan, Ram ...
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Romaine, Simon P ...
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Schork, Nicholas ...
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Shaffer, Jonatha ...
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Shen, Haiqing
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Smith, Erin N.
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van der Most, Pe ...
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van Vliet-Ostapt ...
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Cupples, L. Adri ...
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deJong, Jonas S.
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Delles, Christia ...
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Duggan, David
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Fornage, Myriam
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Furlong, Clement ...
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Glazer, Nicole
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Gums, John G.
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Hastie, Claire
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Holmes, Michael ...
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Illig, Thomas
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Kirkland, Susan ...
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Kivimaki, Mika
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Klein, Ronald
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Klein, Barbara E ...
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Kooperberg, Char ...
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Kottke-Marchant, ...
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Kumari, Meena
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LaCroix, Andrea ...
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Mallela, Laya
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Murugesan, Gurun ...
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Ordovas, Jose
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Ouwehand, Willem ...
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Post, Wendy S.
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Saxena, Richa
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Scharnagl, Huber ...
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Schreiner, Pamel ...
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Shah, Tina
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Shields, Denis C ...
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Shimbo, Daichi
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Srinivasan, Sath ...
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Stolk, Ronald P.
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Swerdlow, Daniel ...
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Taylor Jr, Herma ...
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Topo, Eric J.
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Toskala, Elina
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van Pelt, Joost ...
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van Setten, Jess ...
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Yusuf, Salim
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Whittaker, John ...
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Zwinderman, A. H ...
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Anand, Sonia S.
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Balmforth, Antho ...
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Berenson, Gerald ...
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Bezzina, Connie ...
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Boehm, Bernhard ...
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Boerwinkle, Eric
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Casas, Juan P.
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Caulfield, Mark ...
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Clarke, Robert
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Connell, John M.
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Cruickshanks, Ka ...
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Davidson, Karina ...
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Day, Ian N. M.
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de Bakker, Paul ...
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Doevendans, Piet ...
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Dominiczak, Anna ...
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Hall, Alistair S ...
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Hartman, Cathari ...
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Hengstenberg, Ch ...
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Hillege, Hans L.
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Hofker, Marten H ...
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Humphries, Steve ...
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Jarvik, Gail P.
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Johnson, Julie A ...
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Kaess, Bernhard ...
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Kathiresan, Seka ...
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Koenig, Wolfgang
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Lawlor, Debbie A ...
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Maerz, Winfried
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Melander, Olle
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Montgomery, Gran ...
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Munroe, Patricia ...
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Murray, Sarah S.
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Newhouse, Stephe ...
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Onland-Moret, N. ...
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Poulter, Neil
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Psaty, Bruce
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Redline, Susan
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Rich, Stephen S.
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Rotter, Jerome I ...
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Schunkert, Herib ...
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Sever, Peter
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Shuldiner, Alan ...
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Silverstein, Roy ...
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Stanton, Alice
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Thorand, Barbara
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Trip, Mieke D.
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Tsai, Michael Y.
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van der Harst, P ...
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van der Schoot, ...
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van der Schouw, ...
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Verschuren, W. M ...
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Watkins, Hugh
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Wilde, Arthur A. ...
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Wolffenbuttel, B ...
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Whitfield, John ...
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Hovingh, G. Kees
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Ballantyne, Chri ...
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Wijmenga, Cisca
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Reilly, Muredach ...
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Martin, Nicholas ...
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Wilson, James G.
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Rader, Daniel J.
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Samani, Nilesh J ...
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Reiner, Alex P.
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Hegele, Robert A ...
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Kastelein, John ...
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Hingorani, Aroon ...
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Talmud, Philippa ...
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Hakonarson, Hako ...
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Elbers, Clara C.
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Keating, Brendan ...
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