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High GAD65 autoanti...
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Rolandsson, O
(författare)
High GAD65 autoantibody levels in nondiabetic adults are associated with HLA but not with CTLA-4 or INS VNTR.
- Artikel/kapitelEngelska2003
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LIBRIS-ID:oai:lup.lub.lu.se:199d256e-5936-4c79-ae26-b0245d402fe4
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https://lup.lub.lu.se/record/1127430URI
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https://doi.org/10.1046/j.1365-2796.2003.01115.xDOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
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OBJECTIVES: To explore the relationship between genetic background and antibody levels in a nondiabetic population. We evaluated if high levels of autoantibodies against the 65 kDa isoform of glutamic acid decarboxylase (GAD65Ab), were associated with high-risk genes, i.e. HLA, CTLA-4 and INS VNTR genes. DESIGN AND SUBJECTS: Seventy-five (M/F 39/36) subjects exceeding the 95th percentile of GAD65 autoantibody index and 75 age and sex matched subjects below the 95th percentile, randomly selected amongst participants in the Västerbotten Intervention Programme. METHODS: The GAD65 Ab were measured in a radioligand-binding assay. HLA class II typing was performed by an oligoblot hybridization method. CTLA-4 repeat length was analysed and divided into short forms and long forms. Class I and class III alleles of INS VNTR were detected. Differences in distribution were tested by Pearson chi-square with Yates correction. Odds ratios (OR) were used to compare groups calculated with Cochran's and
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Hägg, E
(författare)
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Janer, M
(författare)
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Rutledge, E
(författare)
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Gaur, L K
(författare)
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Nilsson, M
(författare)
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Hallmans, G
(författare)
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Lernmark, ÅkeLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups(Swepub:lu)endo-ale
(författare)
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Celiaki och diabetesForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Internal Medicine: Wiley253:4, s. 447-4531365-27960954-6820
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