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Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient

Piccini, P (author)
Brooks, D J (author)
Björklund, Anders (author)
Lund University,Lunds universitet,Neurobiologi,Forskargrupper vid Lunds universitet,Neurobiology,Lund University Research Groups
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Gunn, R N (author)
Grasby, P M (author)
Rimoldi, O (author)
Brundin, Patrik (author)
Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
Hagell, Peter (author)
Lund University,Lunds universitet,Äldres hälsa och personcentrerad vård,Forskargrupper vid Lunds universitet,Older people's health and Person-Centred care,Lund University Research Groups
Rehncrona, Stig (author)
Lund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
Widner, Håkan (author)
Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
Lindvall, Olle (author)
Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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 (creator_code:org_t)
Springer Science and Business Media LLC, 1999
1999
English.
In: Nature Neuroscience. - : Springer Science and Business Media LLC. - 1546-1726 .- 1097-6256. ; 2:12, s. 1137-1140
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Synaptic dopamine release from embryonic nigral transplants has been monitored in the striatum of a patient with Parkinson's disease using [11C]-raclopride positron emission tomography to measure dopamine D2 receptor occupancy by the endogenous transmitter. In this patient, who had received a transplant in the right putamen 10 years earlier, grafts had restored both basal and drug-induced dopamine release to normal levels. This was associated with sustained, marked clinical benefit and normalized levels of dopamine storage in the grafted putamen. Despite an ongoing disease process, grafted neurons can thus continue for a decade to store and release dopamine and give rise to substantial symptomatic relief.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

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By the author/editor
Piccini, P
Brooks, D J
Björklund, Ander ...
Gunn, R N
Grasby, P M
Rimoldi, O
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Brundin, Patrik
Hagell, Peter
Rehncrona, Stig
Widner, Håkan
Lindvall, Olle
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About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Neurosciences
Articles in the publication
Nature Neuroscie ...
By the university
Lund University

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P_Piccini
Piccini, P
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