Genetic loci influencing kidney function and chronic kidney disease

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MARC

Chambers, John C. (author)

Genetic loci influencing kidney function and chronic kidney disease

Article/chapterEnglish2010

Publisher, publication year, extent ...

2010-04-11
Springer Science and Business Media LLC,2010

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LIBRIS-ID:oai:lup.lub.lu.se:19f98906-09b8-4ccd-8d8f-b7f361c16278
https://lup.lub.lu.se/record/1619028URI
https://doi.org/10.1038/ng.566DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:120375065URI

Supplementary language notes

Language:English
Summary in:English

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SwePubSwePub

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Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

Notes

Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng

Added entries (persons, corporate bodies, meetings, titles ...)

Zhang, Weihua (author)
Lord, Graham M. (author)
van der Harst, Pim (author)
Lawlor, Debbie A. (author)
Sehmi, Joban S. (author)
Gale, Daniel P. (author)
Wass, Mark N. (author)
Ahmadi, Kourosh R. (author)
Bakker, Stephan J. L. (author)
Beckmann, Jacqui (author)
Bilo, Henk J. G. (author)
Bochud, Murielle (author)
Brown, Morris J. (author)
Caulfield, Mark J. (author)
Connell, John M. C. (author)
Cook, H. Terence (author)
Cotlarciuc, Ioana (author)
Smith, George Davey (author)
de Silva, Ranil (author)
Deng, Guohong (author)
Devuyst, Olivier (author)
Dikkeschei, Lambert D. (author)
Dimkovic, Nada (author)
Dockrell, Mark (author)
Dominiczak, Anna (author)
Ebrahim, Shah (author)
Eggermann, Thomas (author)
Farrall, Martin (author)
Ferrucci, Luigi (author)
Floege, Jurgen (author)
Forouhi, Nita G. (author)
Gansevoort, Ron T. (author)
Han, Xijin (author)
Hedblad, BoLund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups(Swepub:lu)medf-bhe (author)
van der Heide, Jaap J. Homan (author)
Hepkema, Bouke G. (author)
Hernandez-Fuentes, Maria (author)
Hypponen, Elina (author)
Johnson, Toby (author)
de Jong, Paul E. (author)
Kleefstra, Nanne (author)
Lagou, Vasiliki (author)
Lapsley, Marta (author)
Li, Yun (author)
Loos, Ruth J. F. (author)
Luan, Jian'an (author)
Luttropp, KarinKarolinska Institutet (author)
Marechal, Celine (author)
Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome (author)
Munroe, Patricia B. (author)
Nordfors, LouiseKarolinska Institutet (author)
Parsa, Afshin (author)
Peltonen, Leena (author)
Penninx, Brenda W. (author)
Perucha, Esperanza (author)
Pouta, Anneli (author)
Prokopenko, Inga (author)
Roderick, Paul J. (author)
Ruokonen, Aimo (author)
Samani, Nilesh J. (author)
Sanna, Serena (author)
Schalling, MartinKarolinska Institutet (author)
Schlessinger, David (author)
Schlieper, Georg (author)
Seelen, Marc A. J. (author)
Shuldiner, Alan R. (author)
Sjögren, MarketaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Kardiovaskulär forskning - hypertoni,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Cardiovascular Research - Hypertension(Swepub:lu)endo-msj (author)
Smit, Johannes H. (author)
Snieder, Harold (author)
Soranzo, Nicole (author)
Spector, Timothy D. (author)
Stenvinkel, PeterKarolinska Institutet (author)
Sternberg, Michael J. E. (author)
Swaminathan, Ramasamyiyer (author)
Tanaka, Toshiko (author)
Ubink-Veltmaat, Lielith J. (author)
Uda, Manuela (author)
Vollenweider, Peter (author)
Wallace, Chris (author)
Waterworth, Dawn (author)
Zerres, Klaus (author)
Waeber, Gerard (author)
Wareham, Nicholas J. (author)
Maxwell, Patrick H. (author)
McCarthy, Mark I. (author)
Jarvelin, Marjo-Riitta (author)
Mooser, Vincent (author)
Abecasis, Goncalo R. (author)
Lightstone, Liz (author)
Scott, James (author)
Navis, Gerjan (author)
Elliott, Paul (author)
Kooner, Jaspal S. (author)
Kardiovaskulär forskning - epidemiologiForskargrupper vid Lunds universitet (creator_code:org_t)

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In:Nature Genetics: Springer Science and Business Media LLC42:5, s. 373-3751546-17181061-4036

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By the author/editor: Chambers, John C ...; Zhang, Weihua; Lord, Graham M.; van der Harst, P ...; Lawlor, Debbie A ...; Sehmi, Joban S.; show more...; Gale, Daniel P.; Wass, Mark N.; Ahmadi, Kourosh ...; Bakker, Stephan ...; Beckmann, Jacqui; Bilo, Henk J. G.; Bochud, Murielle; Brown, Morris J.; Caulfield, Mark ...; Connell, John M. ...; Cook, H. Terence; Cotlarciuc, Ioan ...; Smith, George Da ...; de Silva, Ranil; Deng, Guohong; Devuyst, Olivier; Dikkeschei, Lamb ...; Dimkovic, Nada; Dockrell, Mark; Dominiczak, Anna; Ebrahim, Shah; Eggermann, Thoma ...; Farrall, Martin; Ferrucci, Luigi; Floege, Jurgen; Forouhi, Nita G.; Gansevoort, Ron ...; Han, Xijin; Hedblad, Bo; van der Heide, J ...; Hepkema, Bouke G ...; Hernandez-Fuente ...; Hypponen, Elina; Johnson, Toby; de Jong, Paul E.; Kleefstra, Nanne; Lagou, Vasiliki; Lapsley, Marta; Li, Yun; Loos, Ruth J. F.; Luan, Jian'an; Luttropp, Karin; Marechal, Celine; Melander, Olle; Munroe, Patricia ...; Nordfors, Louise; Parsa, Afshin; Peltonen, Leena; Penninx, Brenda ...; Perucha, Esperan ...; Pouta, Anneli; Prokopenko, Inga; Roderick, Paul J ...; Ruokonen, Aimo; Samani, Nilesh J ...; Sanna, Serena; Schalling, Marti ...; Schlessinger, Da ...; Schlieper, Georg; Seelen, Marc A. ...; Shuldiner, Alan ...; Sjögren, Marketa; Smit, Johannes H ...; Snieder, Harold; Soranzo, Nicole; Spector, Timothy ...; Stenvinkel, Pete ...; Sternberg, Micha ...; Swaminathan, Ram ...; Tanaka, Toshiko; Ubink-Veltmaat, ...; Uda, Manuela; Vollenweider, Pe ...; Wallace, Chris; Waterworth, Dawn; Zerres, Klaus; Waeber, Gerard; Wareham, Nichola ...; Maxwell, Patrick ...; McCarthy, Mark I ...; Jarvelin, Marjo- ...; Mooser, Vincent; Abecasis, Goncal ...; Lightstone, Liz; Scott, James; Navis, Gerjan; Elliott, Paul; Kooner, Jaspal S ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...

Articles in the publication: Nature Genetics

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