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- Sun, HM (author)
Plasminogen is a critical host pathogenicity factor for group A streptococcal infection
- Article/chapterEnglish2004
Publisher, publication year, extent ...
- American Association for the Advancement of Science (AAAS),2004
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:1a18611a-23d2-4503-8471-27d99fe6967e
- https://lup.lub.lu.se/record/270682URI
- https://doi.org/10.1126/science.1101245DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Group A streptococci, a common human pathogen, secrete streptokinase, which activates the host's blood clot-dissolving protein, plasminogen. Streptokinase is highly specific for human plasminogen, exhibiting little or no activity against other mammalian species, including mouse. Here, a transgene expressing human plasminogen markedly increased mortality in mice infected with streptococci, and this susceptibility was dependent on bacterial streptokinase expression. Thus, streptokinase is a key pathogenicity factor and the primary determinant of host species specificity for group A streptococcal infection. In addition, local fibrin clot formation may be implicated in host defense against microbial pathogens.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Immunologi inom det medicinska området hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Immunology in the medical area hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Mikrobiologi inom det medicinska området hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Microbiology in the medical area hsv//eng
Added entries (persons, corporate bodies, meetings, titles ...)
- Ringdahl, UlrikaLund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)mmb-uri (author)
- Homeister, JW (author)
- Fay, WP (author)
- Engleberg, NC (author)
- Yang, AY (author)
- Rozek, LS (author)
- Wang, XX (author)
- Sjöbring, UlfLund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)mmb-usj (author)
- Ginsburg, D (author)
- Institutionen för immunteknologiInstitutioner vid LTH (creator_code:org_t)
Related titles
- In:Science: American Association for the Advancement of Science (AAAS)305:5688, s. 1283-12861095-92030036-8075
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