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Search: id:"swepub:oai:lup.lub.lu.se:1a191f20-68d3-4f6c-b672-08f529a97c71" > The GTPase domain o...

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  • Lindström, LisaLund University,Lunds universitet,Molekylär patologi, Malmö,Forskargrupper vid Lunds universitet,Molecular Pathology, Malmö,Lund University Research Groups,Skåne University Hospital (author)

The GTPase domain of gamma-tubulin is required for normal mitochondrial function and spatial organization

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-05-03
  • Springer Science and Business Media LLC,2018

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:1a191f20-68d3-4f6c-b672-08f529a97c71
  • https://lup.lub.lu.se/record/1a191f20-68d3-4f6c-b672-08f529a97c71URI
  • https://doi.org/10.1038/s42003-018-0037-3DOI

Supplementary language notes

  • Language:English
  • Summary in:English &Swedish

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • In the cell, γ-tubulin establishes a cellular network of threads named the γ-string meshwork. However, the functions of this meshwork remain to be determined. We investigated the traits of the meshwork and show that γ-strings have the ability to connect the cytoplasm and the mitochondrial DNA together. We also show that γ-tubulin has a role in the maintenance of the mitochondrial network and functions as reduced levels of γ-tubulin or impairment of its GTPase domain disrupts the mitochondrial network and alters both their respiratory capacity and the expression of mitochondrial-related genes. By contrast, reduced mitochondrial number or increased protein levels of γ-tubulin DNA-binding domain enhanced the association of γ-tubulin with mitochondria. Our results demonstrate that γ-tubulin is an important mitochondrial structural component that maintains the mitochondrial network, providing mitochondria with a cellular infrastructure. We propose that γ-tubulin provides a cytoskeletal element that gives form to the mitochondrial network.
  • In the cell, γ-tubulin establishes a cellular network of threads named the γ-string meshwork. However, the functions of this meshwork remain to be determined. We investigated the traits of the meshwork and show that γ-strings have the ability to connect the cytoplasm and the mitochondrial DNA together. We also show that γ-tubulin has a role in the maintenance of the mitochondrial network and functions as reduced levels of γ-tubulin or impairment of its GTPase domain disrupts the mitochondrial network and alters both their respiratory capacity and the expression of mitochondrial-related genes. By contrast, reduced mitochondrial number or increased protein levels of γ-tubulin DNA-binding domain enhanced the association of γ-tubulin with mitochondria. Our results demonstrate that γ-tubulin is an important mitochondrial structural component that maintains the mitochondrial network, providing mitochondria with a cellular infrastructure. We propose that γ-tubulin provides a cytoskeletal element that gives form to the mitochondrial network.

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  • Li, Tongbin (author)
  • Malycheva, DarinaLund University,Lunds universitet,Molekylär patologi, Malmö,Forskargrupper vid Lunds universitet,Molecular Pathology, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)da0682ma (author)
  • Kancharla, ArunLund University (author)
  • Nilsson, HelénLund University,Lunds universitet,Klinisk patologi, Malmö,Forskargrupper vid Lunds universitet,Clinical pathology, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)molm-hn0 (author)
  • Vishnu, NeelanjanLund University,Lunds universitet,Diabetes - molekylär metabolism,Forskargrupper vid Lunds universitet,Diabetes - Molecular Metabolism,Lund University Research Groups(Swepub:lu)med-njv (author)
  • Mulder, HindrikLund University,Lunds universitet,Diabetes - molekylär metabolism,Forskargrupper vid Lunds universitet,Diabetes - Molecular Metabolism,Lund University Research Groups(Swepub:lu)medk-hmu (author)
  • Johansson, MartinLund University,Lunds universitet,Klinisk patologi, Malmö,Forskargrupper vid Lunds universitet,Clinical pathology, Malmö,Lund University Research Groups(Swepub:lu)med-mim (author)
  • Rosselló, Catalina Ana (author)
  • Alvarado-Kristensson, MariaLund University,Lunds universitet,Molekylär patologi, Malmö,Forskargrupper vid Lunds universitet,Molecular Pathology, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)expp-mkr (author)
  • Molekylär patologi, MalmöForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:Communications Biology: Springer Science and Business Media LLC1:https://doi.org/10.1038/s42003-018-0037-32399-3642

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