Search: id:"swepub:oai:lup.lub.lu.se:1a191f20-68d3-4f6c-b672-08f529a97c71" >
The GTPase domain o...
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Lindström, LisaLund University,Lunds universitet,Molekylär patologi, Malmö,Forskargrupper vid Lunds universitet,Molecular Pathology, Malmö,Lund University Research Groups,Skåne University Hospital
(author)
The GTPase domain of gamma-tubulin is required for normal mitochondrial function and spatial organization
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018-05-03
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Springer Science and Business Media LLC,2018
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:1a191f20-68d3-4f6c-b672-08f529a97c71
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https://lup.lub.lu.se/record/1a191f20-68d3-4f6c-b672-08f529a97c71URI
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https://doi.org/10.1038/s42003-018-0037-3DOI
Supplementary language notes
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Language:English
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Summary in:English &Swedish
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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In the cell, γ-tubulin establishes a cellular network of threads named the γ-string meshwork. However, the functions of this meshwork remain to be determined. We investigated the traits of the meshwork and show that γ-strings have the ability to connect the cytoplasm and the mitochondrial DNA together. We also show that γ-tubulin has a role in the maintenance of the mitochondrial network and functions as reduced levels of γ-tubulin or impairment of its GTPase domain disrupts the mitochondrial network and alters both their respiratory capacity and the expression of mitochondrial-related genes. By contrast, reduced mitochondrial number or increased protein levels of γ-tubulin DNA-binding domain enhanced the association of γ-tubulin with mitochondria. Our results demonstrate that γ-tubulin is an important mitochondrial structural component that maintains the mitochondrial network, providing mitochondria with a cellular infrastructure. We propose that γ-tubulin provides a cytoskeletal element that gives form to the mitochondrial network.
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In the cell, γ-tubulin establishes a cellular network of threads named the γ-string meshwork. However, the functions of this meshwork remain to be determined. We investigated the traits of the meshwork and show that γ-strings have the ability to connect the cytoplasm and the mitochondrial DNA together. We also show that γ-tubulin has a role in the maintenance of the mitochondrial network and functions as reduced levels of γ-tubulin or impairment of its GTPase domain disrupts the mitochondrial network and alters both their respiratory capacity and the expression of mitochondrial-related genes. By contrast, reduced mitochondrial number or increased protein levels of γ-tubulin DNA-binding domain enhanced the association of γ-tubulin with mitochondria. Our results demonstrate that γ-tubulin is an important mitochondrial structural component that maintains the mitochondrial network, providing mitochondria with a cellular infrastructure. We propose that γ-tubulin provides a cytoskeletal element that gives form to the mitochondrial network.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Li, Tongbin
(author)
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Malycheva, DarinaLund University,Lunds universitet,Molekylär patologi, Malmö,Forskargrupper vid Lunds universitet,Molecular Pathology, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)da0682ma
(author)
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Kancharla, ArunLund University
(author)
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Nilsson, HelénLund University,Lunds universitet,Klinisk patologi, Malmö,Forskargrupper vid Lunds universitet,Clinical pathology, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)molm-hn0
(author)
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Vishnu, NeelanjanLund University,Lunds universitet,Diabetes - molekylär metabolism,Forskargrupper vid Lunds universitet,Diabetes - Molecular Metabolism,Lund University Research Groups(Swepub:lu)med-njv
(author)
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Mulder, HindrikLund University,Lunds universitet,Diabetes - molekylär metabolism,Forskargrupper vid Lunds universitet,Diabetes - Molecular Metabolism,Lund University Research Groups(Swepub:lu)medk-hmu
(author)
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Johansson, MartinLund University,Lunds universitet,Klinisk patologi, Malmö,Forskargrupper vid Lunds universitet,Clinical pathology, Malmö,Lund University Research Groups(Swepub:lu)med-mim
(author)
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Rosselló, Catalina Ana
(author)
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Alvarado-Kristensson, MariaLund University,Lunds universitet,Molekylär patologi, Malmö,Forskargrupper vid Lunds universitet,Molecular Pathology, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)expp-mkr
(author)
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Molekylär patologi, MalmöForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:Communications Biology: Springer Science and Business Media LLC1:https://doi.org/10.1038/s42003-018-0037-32399-3642
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