A novel gene family encoding proteins with highly differing structure because of a rapidly evolving exon

• Despite vast differences in primary structure, it is here shown that several predominant semen proteins are encoded by genes that belongs to a common family. Members have their transcription unit split into three exons: the first encoding the signal peptide, the second the secreted protein, while the third exon solely consists of 3' non-translated nucleotides. The first and the third exon are conserved between members, but the second exon is not. The genes for human semenogelins I and II, rat SVSII, SVSIV, SVSV and guinea pig GP1 and GP2 belong to this gene family.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medicinal Chemistry (hsv//eng)

Nyckelord

*Prostatic Secretory Proteins

*Multigene Family

Molecular Sequence Data

Male

Humans

Guinea Pigs

Gonadal Steroid Hormones/genetics

*Exons

Molecular

*Evolution

Dna

Conserved Sequence

Animals

Base Sequence

Proteins/*genetics

Rats

Research Support

Non-U.S. Gov't

*Semen

Seminal Plasma Proteins

Seminal Vesicle Secretory Proteins

Sequence Homology

Nucleic Acid

Publikations- och innehållstyp

art (ämneskategori)

ref (ämneskategori)