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Consortium-based ge...
Consortium-based genome-wide meta-analysis for childhood dental caries traits
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- Haworth, Simon (author)
- University of Bristol
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- Shungin, Dmitry (author)
- Umeå universitet,Umeå University,Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA,Institutionen för odontologi
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- Van Der Tas, Justin T. (author)
- Erasmus University Medical Center
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- Vucic, Strahinja (author)
- Erasmus University Medical Center
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- Medina-Gomez, Carolina (author)
- Erasmus University Medical Center
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- Yakimov, Victor (author)
- Danish Serum Institute, Copenhagen
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- Feenstra, Bjarke (author)
- Danish Serum Institute, Copenhagen
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- Shaffer, John R. (author)
- University of Pittsburgh
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- Lee, Myoung Keun (author)
- University of Pittsburgh
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- Standl, Marie (author)
- Helmholtz Zentrum München
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- Thiering, Elisabeth (author)
- Helmholtz Zentrum München,German Center for Lung Research (DZL)
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- Wang, Carol (author)
- University of Western Australia, Crawley
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- Bønnelykke, Klaus (author)
- University of Copenhagen
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- Waage, Johannes (author)
- University of Copenhagen
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- Jessen, Leon Eyrich (author)
- University of Copenhagen
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- Nørrisgaard, Pia Elisabeth (author)
- University of Copenhagen
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- Joro, Raimo (author)
- University of Eastern Finland
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- Seppälä, Ilkka (author)
- University of Tampere
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- Raitakari, Olli (author)
- Turku University Hospital,University of Turku
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- Dudding, Tom (author)
- University of Bristol
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- Grgic, Olja (author)
- Erasmus University Medical Center
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- Ongkosuwito, Edwin (author)
- Erasmus University Medical Center
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- Vierola, Anu (author)
- University of Eastern Finland
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- Eloranta, Aino Maija (author)
- University of Eastern Finland
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- West, Nicola X. (author)
- University of Bristol
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- Thomas, Steven J. (author)
- University of Bristol
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- McNeil, Daniel W. (author)
- University of West Virginia
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- Levy, Steven M. (author)
- University of Iowa,Danish Serum Institute, Copenhagen,Stanford University,University of Copenhagen
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- Slayton, Rebecca (author)
- University of Washington
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- Nohr, Ellen A. (author)
- University of Southern Denmark
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- Lehtimäki, Terho (author)
- Erasmus University Medical Center
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- Lakka, Timo (author)
- Kuopio University Hospital,University of Eastern Finland
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- Bisgaard, Hans (author)
- University of Copenhagen
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- Pennell, Craig (author)
- University of Western Australia, Crawley
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- Kühnisch, Jan (author)
- German Center for Lung Research (DZL)
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- Marazita, Mary L. (author)
- University of Pittsburgh
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- Melbye, Mads (author)
- Danish Serum Institute, Copenhagen,Stanford University,University of Copenhagen
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- Geller, Frank (author)
- Danish Serum Institute, Copenhagen
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- Rivadeneira, Fernando (author)
- Erasmus University Medical Center
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- Wolvius, Eppo B. (author)
- Erasmus University Medical Center
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- Franks, Paul W. (author)
- Umeå universitet,Umeå University,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö 202 13, Sweden; Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA,Avdelningen för medicin
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- Johansson, Ingegerd (author)
- Umeå universitet,Umeå University,Institutionen för odontologi
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- Timpson, Nicholas J. (author)
- University of Bristol
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(creator_code:org_t)
- 2018-06-20
- 2018
- English.
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In: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 27:17, s. 3113-3127
- Related links:
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http://dx.doi.org/10... (free)
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https://academic.oup...
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Prior studies suggest dental caries traits in children and adolescents are partially heritable, but there has been no large-scale consortium genome-wide association study (GWAS) to date. We therefore performed GWAS for caries in participants aged 2.5-18.0 years from nine contributing centres. Phenotype definitions were created for the presence or absence of treated or untreated caries, stratified by primary and permanent dentition. All studies tested for association between caries and genotype dosage and the results were combined using fixed-effects meta-analysis. Analysis included up to 19 003 individuals (7530 affected) for primary teeth and 13 353 individuals (5875 affected) for permanent teeth. Evidence for association with caries status was observed at rs1594318-C for primary teeth [intronic within ALLC, odds ratio (OR) 0.85, effect allele frequency (EAF) 0.60, P 4.13e-8] and rs7738851-A (intronic within NEDD9, OR 1.28, EAF 0.85, P 1.63e-8) for permanent teeth. Consortiumwide estimated heritability of caries was low [h2 of 1% (95% CI: 0%: 7%) and 6% (95% CI 0%: 13%) for primary and permanent dentitions, respectively] compared with corresponding within-study estimates [h2 of 28% (95% CI: 9%: 48%) and 17% (95% CI: 2%: 31%)] or previously published estimates. This study was designed to identify common genetic variants with modest effects which are consistent across different populations. We found few single variants associated with caries status under these assumptions. Phenotypic heterogeneity between cohorts and limited statistical power will have contributed; these findings could also reflect complexity not captured by our study design, such as genetic effects which are conditional on environmental exposure.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Haworth, Simon
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Shungin, Dmitry
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Van Der Tas, Jus ...
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Vucic, Strahinja
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Medina-Gomez, Ca ...
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Yakimov, Victor
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show more...
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Feenstra, Bjarke
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Shaffer, John R.
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Lee, Myoung Keun
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Standl, Marie
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Thiering, Elisab ...
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Wang, Carol
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Bønnelykke, Klau ...
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Waage, Johannes
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Jessen, Leon Eyr ...
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Nørrisgaard, Pia ...
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Joro, Raimo
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Seppälä, Ilkka
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Raitakari, Olli
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Dudding, Tom
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Grgic, Olja
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Ongkosuwito, Edw ...
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Vierola, Anu
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Eloranta, Aino M ...
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West, Nicola X.
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Thomas, Steven J ...
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McNeil, Daniel W ...
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Levy, Steven M.
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Slayton, Rebecca
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Nohr, Ellen A.
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Lehtimäki, Terho
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Lakka, Timo
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Bisgaard, Hans
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Pennell, Craig
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Kühnisch, Jan
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Marazita, Mary L ...
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Melbye, Mads
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Geller, Frank
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Rivadeneira, Fer ...
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Wolvius, Eppo B.
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Franks, Paul W.
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Johansson, Ingeg ...
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Timpson, Nichola ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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Human Molecular ...
- By the university
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Lund University
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Umeå University