SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Grundfest WS)
 

Search: WFRF:(Grundfest WS) > (1996) > Laser-induced fluor...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • af Klinteberg, C (author)

Laser-induced fluorescence diagnostics of basal cell carcinomas of the skin following topical ALA application

  • Article/chapterEnglish1996

Publisher, publication year, extent ...

  • SPIE,1996
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:1a902804-8961-4ae8-825a-871a76cab61b
  • ISBN:0819423289
  • https://lup.lub.lu.se/record/2260477URI
  • https://doi.org/10.1117/12.260817DOI
  • https://research.chalmers.se/publication/169495URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:kon swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Fourteen patients with superficial basal cell carcinomas (BCCs) and fifteen patients with nodular BCCs were investigated by means of laser-induced fluorescence (LIF) in connection with photodynamic therapy (PDT). Topical application of delta-amino levulinic acid (ALA) was performed six hours prior to the treatment session. Fluorescence spectra were recorded, using a point-monitoring system with an excitation wavelength of 405 nm. The measurements were performed in scans over the lesion and the surrounding normal skin before application of ALA, and immediately before and after the laser treatment. The selective uptake of the photosensitiser resulted in a fluorescence intensity ratio of 2.4:1 for superficial BCCs and 2.5:1 for nodular BCCs. If the fluorescence intensity was divided by the autofluorescence, this resulted in a contrast enhancement of about a factor 6 for tumour tissue. In seven patients (five with nodular BCC and two with superficial BCC), additional fluorescence measurements were performed two and four hours following the ALA application, and two hours after the PDT procedure. Thus, the kinetics of the transformation of ACA to protoporphyrin IX (PpIX) could be followed, which indicated that the synthesis of PpIX was more rapid in the tumour than in the normal tissue. After four hours, the PpIX level inside the tumour was saturated, while there still was an accumulation in the surrounding skin. The highest contrast between tumour and normal skin was reached within two hours after the ALA application.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Nilsson, Annika,1969 (author)
  • Wang, I (author)
  • Andersson-Engels, StefanLund University,Lunds universitet,Atomfysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Atomic Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)fysi-san (author)
  • Svanberg, SuneLund University,Lunds universitet,Atomfysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Atomic Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)fysi-ssv (author)
  • Svanberg, KatarinaLund University,Lunds universitet,Atomfysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Atomic Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)onk-ksv (author)
  • Bigio, IJ (editor)
  • Grundfest, WS (editor)
  • Schneckenburger, H (editor)
  • Svanberg, Katarina (editor)
  • Viallet, PM (editor)
  • Katzir, A (editor)
  • AtomfysikFysiska institutionen (creator_code:org_t)

Related titles

  • In:Optical Biopsies and Microscopic Techniques, Proceedings of: SPIE2926, s. 32-400819423289

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view