Early efficacy of budesonide/formoterol in patients with moderate-to-very-severe COPD

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Calverley, Peter M.Aintree University Hospital (author)

Early efficacy of budesonide/formoterol in patients with moderate-to-very-severe COPD

Article/chapterEnglish2017

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2017
13 s.

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LIBRIS-ID:oai:lup.lub.lu.se:1ad2440b-6aff-428a-bffb-2dad47dc51c4
https://lup.lub.lu.se/record/1ad2440b-6aff-428a-bffb-2dad47dc51c4URI
https://doi.org/10.2147/COPD.S114209DOI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype

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Background and objective: Large clinical trials have confirmed the long-term efficacy of inhaled corticosteroid/long-acting β2-agonist combinations in patients with chronic obstructive pulmonary disease (COPD). It was hypothesized that significant treatment effects would already be present within 3 months after the initiation of treatment across a range of clinical outcomes, irrespective of COPD severity. Methods: Post hoc analysis of 3-month post-randomization outcomes, including exacerbation rates, dropouts, symptoms, reliever use, and lung function, from three studies with similar inclusion criteria of moderate-to-very-severe COPD. Patients (n=1,571) were treated with budesonide/formoterol (B/F) 320/9 μg or placebo, twice daily; in one study, tiotropium 18 μg once daily was also given. Results: Over the first 3 months of treatment, fewer patients randomized to B/F experienced exacerbations versus the placebo group (111 and 196 patients with ≥1 exacerbation, respectively). This was true in each COPD severity group. Compared with placebo, B/F treatment led to significantly lower 3-month exacerbation rates in the moderate and severe COPD severity groups (46% and 57% reduction, respectively), with a nonsignificant reduction (29%) in very severe COPD. Fewer dropouts occurred among patients treated with B/F versus placebo, this effect being greater with increasing COPD severity. B/F was associated with improved forced expiratory volume in 1 s, morning peak expiratory flow rate, total reliever use, and total symptom score versus placebo. Conclusion: Treatment with B/F decreased exacerbations in patients with moderate-to-very-severe COPD within 3 months of commencing treatment. This effect was paralleled by improved lung function, less reliever medication use, and fewer symptoms, irrespective of disease severity.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Lungmedicin och allergi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Respiratory Medicine and Allergy hsv//eng
Bronchodilator agents
Clinical respiratory medicine
Clinical trials
COPD

Added entries (persons, corporate bodies, meetings, titles ...)

Eriksson, GöranLund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)med-geo (author)
Jenkins, Christine R.University of Sydney (author)
Anzueto, Antonio R.University of Texas (author)
Make, Barry J.University of Colorado (author)
Persson, AndersAstraZeneca, Sweden (author)
Fagerås, MalinAstraZeneca, Sweden (author)
Postma, Dirkje S.University of Groningen (author)
Aintree University HospitalLungmedicin, allergologi och palliativ medicin (creator_code:org_t)

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In:International Journal of COPD12, s. 13-251176-9106

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