SwePub
Sök i LIBRIS databas

  Extended search

(onr:"swepub:oai:lup.lub.lu.se:1b1b8025-c7c5-4a73-93c8-df379947f105")
 

Search: (onr:"swepub:oai:lup.lub.lu.se:1b1b8025-c7c5-4a73-93c8-df379947f105") > Soluble urokinase p...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Enocsson, HelenaLinköpings universitet,Linköping University,Avdelningen för inflammation och infektion,Medicinska fakulteten (author)

Soluble urokinase plasminogen activator receptor (suPAR) levels predict damage accrual in patients with recent-onset systemic lupus erythematosus

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • Elsevier BV,2020

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:1b1b8025-c7c5-4a73-93c8-df379947f105
  • https://lup.lub.lu.se/record/1b1b8025-c7c5-4a73-93c8-df379947f105URI
  • https://doi.org/10.1016/j.jaut.2019.102340DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:142834391URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-163458URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Funding Agencies|Swedish Rheumatism Association; Region Ostergotland (ALF Grants); King Gustaf Vs 80-year Anniversary Foundation; King Gustaf V and Queen Victorias Freemasons Foundation; Versus ArthritisVersus Arthritis; NIHR Manchester Biomedical Research CentreNational Institute for Health Research (NIHR); NIHR/Welcome Trust Manchester Clinical Research Facility; Lupus UK; Sandwell and West Birmingham Hospitals NHS Trust; National Institute for Health Research (NIHR)/Wellcome Trust Birmingham Clinical Research Facility; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [8UL1TR000150]; National Research Foundation of KoreaNational Research Foundation of Korea [NRF-2017M3A9B4050335]
  • Objective: The soluble urokinase plasminogen activator receptor (suPAR) has potential as a prognosis and severity biomarker in several inflammatory and infectious diseases. In a previous cross-sectional study, suPAR levels were shown to reflect damage accrual in cases of systemic lupus erythematosus (SLE). Herein, we evaluated suPAR as a predictor of future organ damage in recent-onset SLE. Methods: Included were 344 patients from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort who met the 1997 American College of Rheumatology classification criteria with 5-years of follow-up data available. Baseline sera from patients and age- and sex-matched controls were assayed for suPAR. Organ damage was assessed annually using the SLICC/ACR damage index (SDI). Results: The levels of suPAR were higher in patients who accrued damage, particularly those with SDI≥2 at 5 years (N = 32, 46.8% increase, p = 0.004), as compared to patients without damage. Logistic regression analysis revealed a significant impact of suPAR on SDI outcome (SDI≥2; OR = 1.14; 95% CI 1.03–1.26), also after adjustment for confounding factors. In an optimized logistic regression to predict damage, suPAR persisted as a predictor, together with baseline disease activity (SLEDAI-2K), age, and non-Caucasian ethnicity (model AUC = 0.77). Dissecting SDI into organ systems revealed higher suPAR levels in patients who developed musculoskeletal damage (SDI≥1; p = 0.007). Conclusion: Prognostic biomarkers identify patients who are at risk of acquiring early damage and therefore need careful observation and targeted treatment strategies. Overall, suPAR constitutes an interesting biomarker for patient stratification and for identifying SLE patients who are at risk of acquiring organ damage during the first 5 years of disease.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Wirestam, LinaLinköpings universitet,Linköping University,Avdelningen för inflammation och infektion,Medicinska fakulteten(Swepub:liu)linwi45 (author)
  • Dahle, Charlotte,1956-Linköpings universitet,Linköping University,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Klinisk immunologi och transfusionsmedicin(Swepub:liu)chada46 (author)
  • Padyukov, LeonidKarolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden (author)
  • Jönsen, AndreasLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Lund Univ, Sweden(Swepub:lu)reum-ajo (author)
  • Urowitz, Murray B.University of Toronto,Toronto Western Hosp, Canada; Univ Toronto, Canada (author)
  • Gladman, Dafna D.University of Toronto,Toronto Western Hosp, Canada; Univ Toronto, Canada (author)
  • Romero-Diaz, JuanitaSalvador Zubirán National Institute of Health Sciences and Nutrition,Inst Nacl Ciencias Med and Nutr Salvador Zubiran, Mexico (author)
  • Bae, Sang CheolHanyang University,Hanyang Univ, South Korea (author)
  • Fortin, Paul R.Laval University,Univ Laval, Canada (author)
  • Sanchez-Guerrero, JorgeUniversity of Toronto,Toronto Western Hosp, Canada; Univ Toronto, Canada (author)
  • Clarke, Ann E.University of Calgary,Univ Calgary, Canada (author)
  • Bernatsky, SashaMcGill University Health Center,McGill Univ, Canada (author)
  • Gordon, CarolineUniversity of Birmingham,Univ Birmingham, England (author)
  • Hanly, John G.Dalhousie University,Queen Elizabeth 2 Hlth Sci Ctr, Canada; Queen Elizabeth 2 Hlth Sci Ctr, Canada; Dalhousie Univ, Canada (author)
  • Wallace, Daniel J.University of California, Los Angeles,Univ Calif Los Angeles, CA USA (author)
  • Isenberg, David A.University College London,UCL, England,Columbia Univ, NY USA (author)
  • Rahman, AnisurUniversity College London,UCL, England (author)
  • Merrill, Joan T.Oklahoma Medical Research Foundation,Oklahoma Med Res Fdn, OK 73104 USA (author)
  • Ginzler, EllenSUNY Downstate Health Sciences University,Suny Downstate Med Ctr, NY 11203 USA (author)
  • Alarcón, Graciela S.University of Alabama,Univ Alabama Birmingham, AL 35294 USA (author)
  • Chatham, W. WinnUniversity of Alabama,Univ Alabama Birmingham, AL 35294 USA (author)
  • Petri, MichelleJohns Hopkins University School of Medicine,Johns Hopkins Univ, MD USA (author)
  • Khamashta, MuntherUniversity College London,Kings Coll London, England (author)
  • Aranow, CynthiaFeinstein Institute for Medical Research,Feinstein Inst Med Res, NY USA (author)
  • Mackay, MegganFeinstein Institute for Medical Research,Feinstein Inst Med Res, NY USA (author)
  • Dooley, Mary AnneUniversity of North Carolina,Univ N Carolina, NC 27515 USA (author)
  • Manzi, SusanAllegheny Hlth Network, PA USA (author)
  • Ramsey-Goldman, RosalindNorthwestern University Feinberg School of Medicine,Northwestern Univ, IL 60611 USA; Feinberg Sch Med, IL USA (author)
  • Nived, OlaLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Sweden(Swepub:lu)reum-oni (author)
  • Steinsson, KristjanNational University Hospital of Iceland,Landspitali Univ Hosp, Iceland (author)
  • Zoma, Asad A.Hairmyres Hospital,Hairmyres Hosp, Scotland (author)
  • Ruiz-Irastorza, GuillermoUniversity of the Basque Country,Univ Basque Country, Spain (author)
  • Lim, S. SamEmory University,Emory Univ, GA USA (author)
  • Kalunian, Kenneth C.University of California, San Diego,UCSD Sch Med, CA USA (author)
  • Inanc, MuratIstanbul Univ, Turkey (author)
  • van Vollenhoven, Ronald F.Karolinska Institutet,Univ Amsterdam, Netherlands; Free Univ VU Amsterdam, Netherlands; Amsterdam Rheumatol and Immunol Ctr, Netherlands (author)
  • Ramos-Casals, ManuelHospital Clínic of Barcelona,Hosp Clin Barcelona, Spain (author)
  • Kamen, Diane L.Medical University of South Carolina,Med Univ South Carolina, SC 29425 USA (author)
  • Jacobsen, SørenCopenhagen University Hospital,Copenhagen Univ Hosp, Denmark (author)
  • Peschken, Christine A.University of Manitoba,Univ Manitoba, Canada (author)
  • Askanase, AncaColumbia University (author)
  • Stoll, ThomasBern University Hospital,Kantousspital, Switzerland (author)
  • Bruce, Ian N.University of Manchester,Univ Manchester, England; Manchester Univ Hosp NHS Fdn Trust, England (author)
  • Wetterö, JonasLinköpings universitet,Linköping University,Avdelningen för inflammation och infektion,Medicinska fakulteten(Swepub:liu)jonwe26 (author)
  • Sjöwall, Christopher,1975-Linköpings universitet,Linköping University,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland(Swepub:liu)chrsj93 (author)
  • Linköping UniversityAvdelningen för inflammation och infektion (creator_code:org_t)

Related titles

  • In:Journal of Autoimmunity: Elsevier BV1060896-84111095-9157

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view