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Soluble urokinase p...
Soluble urokinase plasminogen activator receptor (suPAR) levels predict damage accrual in patients with recent-onset systemic lupus erythematosus
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- Enocsson, Helena (author)
- Linköpings universitet,Linköping University,Avdelningen för inflammation och infektion,Medicinska fakulteten
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- Wirestam, Lina (author)
- Linköpings universitet,Linköping University,Avdelningen för inflammation och infektion,Medicinska fakulteten
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- Dahle, Charlotte, 1956- (author)
- Linköpings universitet,Linköping University,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Klinisk immunologi och transfusionsmedicin
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- Padyukov, Leonid (author)
- Karolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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- Jönsen, Andreas (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Lund Univ, Sweden
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- Urowitz, Murray B. (author)
- University of Toronto,Toronto Western Hosp, Canada; Univ Toronto, Canada
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- Gladman, Dafna D. (author)
- University of Toronto,Toronto Western Hosp, Canada; Univ Toronto, Canada
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- Romero-Diaz, Juanita (author)
- Salvador Zubirán National Institute of Health Sciences and Nutrition,Inst Nacl Ciencias Med and Nutr Salvador Zubiran, Mexico
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- Bae, Sang Cheol (author)
- Hanyang University,Hanyang Univ, South Korea
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- Fortin, Paul R. (author)
- Laval University,Univ Laval, Canada
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- Sanchez-Guerrero, Jorge (author)
- University of Toronto,Toronto Western Hosp, Canada; Univ Toronto, Canada
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- Clarke, Ann E. (author)
- University of Calgary,Univ Calgary, Canada
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- Bernatsky, Sasha (author)
- McGill University Health Center,McGill Univ, Canada
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- Gordon, Caroline (author)
- University of Birmingham,Univ Birmingham, England
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- Hanly, John G. (author)
- Dalhousie University,Queen Elizabeth 2 Hlth Sci Ctr, Canada; Queen Elizabeth 2 Hlth Sci Ctr, Canada; Dalhousie Univ, Canada
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- Wallace, Daniel J. (author)
- University of California, Los Angeles,Univ Calif Los Angeles, CA USA
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- Isenberg, David A. (author)
- University College London,UCL, England,Columbia Univ, NY USA
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- Rahman, Anisur (author)
- University College London,UCL, England
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- Merrill, Joan T. (author)
- Oklahoma Medical Research Foundation,Oklahoma Med Res Fdn, OK 73104 USA
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- Ginzler, Ellen (author)
- SUNY Downstate Health Sciences University,Suny Downstate Med Ctr, NY 11203 USA
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- Alarcón, Graciela S. (author)
- University of Alabama,Univ Alabama Birmingham, AL 35294 USA
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- Chatham, W. Winn (author)
- University of Alabama,Univ Alabama Birmingham, AL 35294 USA
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- Petri, Michelle (author)
- Johns Hopkins University School of Medicine,Johns Hopkins Univ, MD USA
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- Khamashta, Munther (author)
- University College London,Kings Coll London, England
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- Aranow, Cynthia (author)
- Feinstein Institute for Medical Research,Feinstein Inst Med Res, NY USA
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- Mackay, Meggan (author)
- Feinstein Institute for Medical Research,Feinstein Inst Med Res, NY USA
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- Dooley, Mary Anne (author)
- University of North Carolina,Univ N Carolina, NC 27515 USA
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- Manzi, Susan (author)
- Allegheny Hlth Network, PA USA
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- Ramsey-Goldman, Rosalind (author)
- Northwestern University Feinberg School of Medicine,Northwestern Univ, IL 60611 USA; Feinberg Sch Med, IL USA
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- Nived, Ola (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Sweden
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- Steinsson, Kristjan (author)
- National University Hospital of Iceland,Landspitali Univ Hosp, Iceland
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- Zoma, Asad A. (author)
- Hairmyres Hospital,Hairmyres Hosp, Scotland
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- Ruiz-Irastorza, Guillermo (author)
- University of the Basque Country,Univ Basque Country, Spain
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- Lim, S. Sam (author)
- Emory University,Emory Univ, GA USA
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- Kalunian, Kenneth C. (author)
- University of California, San Diego,UCSD Sch Med, CA USA
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- Inanc, Murat (author)
- Istanbul Univ, Turkey
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- van Vollenhoven, Ronald F. (author)
- Karolinska Institutet,Univ Amsterdam, Netherlands; Free Univ VU Amsterdam, Netherlands; Amsterdam Rheumatol and Immunol Ctr, Netherlands
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- Ramos-Casals, Manuel (author)
- Hospital Clínic of Barcelona,Hosp Clin Barcelona, Spain
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- Kamen, Diane L. (author)
- Medical University of South Carolina,Med Univ South Carolina, SC 29425 USA
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- Jacobsen, Søren (author)
- Copenhagen University Hospital,Copenhagen Univ Hosp, Denmark
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- Peschken, Christine A. (author)
- University of Manitoba,Univ Manitoba, Canada
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- Askanase, Anca (author)
- Columbia University
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- Stoll, Thomas (author)
- Bern University Hospital,Kantousspital, Switzerland
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- Bruce, Ian N. (author)
- University of Manchester,Univ Manchester, England; Manchester Univ Hosp NHS Fdn Trust, England
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- Wetterö, Jonas (author)
- Linköpings universitet,Linköping University,Avdelningen för inflammation och infektion,Medicinska fakulteten
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- Sjöwall, Christopher, 1975- (author)
- Linköpings universitet,Linköping University,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English.
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In: Journal of Autoimmunity. - : Elsevier BV. - 0896-8411 .- 1095-9157. ; 106
- Related links:
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://liu.diva-por... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Objective: The soluble urokinase plasminogen activator receptor (suPAR) has potential as a prognosis and severity biomarker in several inflammatory and infectious diseases. In a previous cross-sectional study, suPAR levels were shown to reflect damage accrual in cases of systemic lupus erythematosus (SLE). Herein, we evaluated suPAR as a predictor of future organ damage in recent-onset SLE. Methods: Included were 344 patients from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort who met the 1997 American College of Rheumatology classification criteria with 5-years of follow-up data available. Baseline sera from patients and age- and sex-matched controls were assayed for suPAR. Organ damage was assessed annually using the SLICC/ACR damage index (SDI). Results: The levels of suPAR were higher in patients who accrued damage, particularly those with SDI≥2 at 5 years (N = 32, 46.8% increase, p = 0.004), as compared to patients without damage. Logistic regression analysis revealed a significant impact of suPAR on SDI outcome (SDI≥2; OR = 1.14; 95% CI 1.03–1.26), also after adjustment for confounding factors. In an optimized logistic regression to predict damage, suPAR persisted as a predictor, together with baseline disease activity (SLEDAI-2K), age, and non-Caucasian ethnicity (model AUC = 0.77). Dissecting SDI into organ systems revealed higher suPAR levels in patients who developed musculoskeletal damage (SDI≥1; p = 0.007). Conclusion: Prognostic biomarkers identify patients who are at risk of acquiring early damage and therefore need careful observation and targeted treatment strategies. Overall, suPAR constitutes an interesting biomarker for patient stratification and for identifying SLE patients who are at risk of acquiring organ damage during the first 5 years of disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Biomarker
- Organ damage
- Outcome
- Prognosis
- SLE
- Biomarker; SLE; Organ damage; Prognosis; Outcome
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Enocsson, Helena
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Wirestam, Lina
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Dahle, Charlotte ...
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Padyukov, Leonid
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Jönsen, Andreas
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Urowitz, Murray ...
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show more...
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Gladman, Dafna D ...
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Romero-Diaz, Jua ...
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Bae, Sang Cheol
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Fortin, Paul R.
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Sanchez-Guerrero ...
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Clarke, Ann E.
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Bernatsky, Sasha
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Gordon, Caroline
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Hanly, John G.
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Wallace, Daniel ...
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Isenberg, David ...
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Rahman, Anisur
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Merrill, Joan T.
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Ginzler, Ellen
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Alarcón, Graciel ...
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Chatham, W. Winn
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Petri, Michelle
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Khamashta, Munth ...
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Aranow, Cynthia
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Mackay, Meggan
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Dooley, Mary Ann ...
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Manzi, Susan
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Ramsey-Goldman, ...
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Nived, Ola
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Steinsson, Krist ...
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Zoma, Asad A.
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Ruiz-Irastorza, ...
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Lim, S. Sam
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Kalunian, Kennet ...
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Inanc, Murat
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van Vollenhoven, ...
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Ramos-Casals, Ma ...
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Kamen, Diane L.
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Jacobsen, Søren
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Peschken, Christ ...
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Askanase, Anca
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Stoll, Thomas
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Bruce, Ian N.
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Wetterö, Jonas
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Sjöwall, Christo ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Journal of Autoi ...
- By the university
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Lund University
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Karolinska Institutet
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Linköping University