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Genetic Interaction...
Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation : The AFGen Consortium
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- Weng, Lu Chen (author)
- Broad Institute,Massachusetts General Hospital
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- Lunetta, Kathryn L (author)
- Boston University
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- Müller-Nurasyid, Martina (author)
- University Hospital Munich,Helmholtz Zentrum München,Ludwig-Maximilian University of Munich,German Centre for Cardiovascular Research
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- Smith, Albert Vernon (author)
- University of Iceland,Icelandic Heart Association
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- Thériault, Sébastien (author)
- McMaster University
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- Weeke, Peter E. (author)
- Vanderbilt University,Copenhagen University Hospital
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- Barnard, John (author)
- Cleveland Clinic Foundation
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- Bis, Joshua C. (author)
- University of Washington
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- Lyytikäinen, Leo-Pekka (author)
- University of Tampere
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- Kleber, Marcus E (author)
- Heidelberg University
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- Martinsson, Andreas (author)
- Lund University,Lunds universitet,Molecular Epidemiology and Cardiology,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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- Lin, Henry J. (author)
- University of California, Los Angeles
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- Rienstra, Michiel (author)
- University of Groningen
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- Trompet, Stella (author)
- Leiden University Medical Centre
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- Krijthe, Bouwe P (author)
- Erasmus University Medical Center
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- Dörr, Marcus (author)
- University Medicine Greifswald,German Centre for Cardiovascular Research
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- Klarin, Derek (author)
- Harvard University,Massachusetts General Hospital,Broad Institute
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- Chasman, Daniel I. (author)
- Brigham and Women's Hospital / Harvard Medical School
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- Sinner, Moritz F (author)
- Ludwig-Maximilian University of Munich,German Centre for Cardiovascular Research
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- Waldenberger, Melanie (author)
- Helmholtz Zentrum München,German Centre for Cardiovascular Research
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- Launer, Lenore J. (author)
- National Institute on Aging, United States
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- Harris, Tamara B (author)
- National Institute on Aging, United States
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- Soliman, Elsayed Z (author)
- Wake Forest University
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- Alonso, Alvaro (author)
- Emory University
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- Paré, Guillaume (author)
- McMaster University
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- Teixeira, Pedro L. (author)
- Vanderbilt University
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- Denny, Joshua C (author)
- Vanderbilt University
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- Shoemaker, M. Benjamin (author)
- Vanderbilt University
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- Van Wagoner, David R (author)
- Cleveland Clinic Foundation
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- Smith, Jonathan D (author)
- Cleveland Clinic Foundation
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- Psaty, Bruce M. (author)
- University of Washington,Kaiser Permanente Research Institute
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- Sotoodehnia, Nona (author)
- Kaiser Permanente Research Institute,University of Washington
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- Taylor, Kent D (author)
- University of California, Los Angeles
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- Kähönen, Mika (author)
- Tampere University Hospital,University of Tampere
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- Nikus, Kjell (author)
- University of Tampere,Tampere University Hospital
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- Delgado, Graciela E. (author)
- Heidelberg University
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital
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- Engström, Gunnar (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
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- Yao, Jie (author)
- University of California, Los Angeles
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- Guo, Xiuqing (author)
- University of California, Los Angeles
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- Christophersen, Ingrid E. (author)
- Baerum Hospital,Massachusetts General Hospital,Broad Institute
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- Ellinor, Patrick T (author)
- Massachusetts General Hospital,Broad Institute
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- Geelhoed, Bastiaan (author)
- University of Groningen
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- Verweij, Niek (author)
- University of Groningen
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- Macfarlane, Peter (author)
- University of Glasgow
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- Ford, Ian (author)
- University of Glasgow
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- Heeringa, Jan (author)
- Erasmus University Medical Center
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- Franco, Oscar H (author)
- Erasmus University Medical Center
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- Uitterlinden, André G (author)
- Erasmus University Medical Center
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- Völker, Uwe (author)
- German Centre for Cardiovascular Research,University Medicine Greifswald
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- Teumer, Alexander (author)
- University Medicine Greifswald,German Centre for Cardiovascular Research
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- Rose, Lynda M. (author)
- Brigham and Women's Hospital / Harvard Medical School
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- Kääb, Stefan (author)
- Ludwig-Maximilian University of Munich,German Centre for Cardiovascular Research
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- Gudnason, Vilmundur (author)
- University of Iceland,Icelandic Heart Association
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- Arking, Dan E. (author)
- Johns Hopkins University
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- Conen, David (author)
- University Hospital Basel
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- Roden, Dan M (author)
- Vanderbilt University
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- Chung, Mina K (author)
- Cleveland Clinic Foundation
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- Heckbert, Susan R (author)
- Kaiser Permanente Research Institute,University of Washington
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- Benjamin, Emelia J (author)
- Boston University
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- Lehtimäki, Terho (author)
- University of Tampere
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- März, Winfried (author)
- Medical University of Graz,Heidelberg University
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- Smith, Gustav (author)
- Lund University,Lunds universitet,Molecular Epidemiology and Cardiology,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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- Rotter, Jerome I. (author)
- University of California, Los Angeles
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- van der Harst, Pim (author)
- University of Groningen
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- Jukema, J. Wouter (author)
- Interuniversity Cardiology Institute of the Netherlands,Leiden University Medical Centre
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- Stricker, Bruno H (author)
- Dutch Health Care Inspectorate,Erasmus University Medical Center
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- Felix, Stephan B (author)
- German Centre for Cardiovascular Research,University Medicine Greifswald
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- Albert, Christine M (author)
- Brigham and Women's Hospital / Harvard Medical School
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- Lubitz, Steven A (author)
- Massachusetts General Hospital,Broad Institute
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(creator_code:org_t)
- 2017-09-12
- 2017
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7:1
- Related links:
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http://dx.doi.org/10... (free)
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https://www.nature.c...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- It is unclear whether genetic markers interact with risk factors to influence atrial fibrillation (AF) risk. We performed genome-wide interaction analyses between genetic variants and age, sex, hypertension, and body mass index in the AFGen Consortium. Study-specific results were combined using meta-analysis (88,383 individuals of European descent, including 7,292 with AF). Variants with nominal interaction associations in the discovery analysis were tested for association in four independent studies (131,441 individuals, including 5,722 with AF). In the discovery analysis, the AF risk associated with the minor rs6817105 allele (at the PITX2 locus) was greater among subjects ≤ 65 years of age than among those > 65 years (interaction p-value = 4.0 × 10-5). The interaction p-value exceeded genome-wide significance in combined discovery and replication analyses (interaction p-value = 1.7 × 10-8). We observed one genome-wide significant interaction with body mass index and several suggestive interactions with age, sex, and body mass index in the discovery analysis. However, none was replicated in the independent sample. Our findings suggest that the pathogenesis of AF may differ according to age in individuals of European descent, but we did not observe evidence of statistically significant genetic interactions with sex, body mass index, or hypertension on AF risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Weng, Lu Chen
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Lunetta, Kathryn ...
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Müller-Nurasyid, ...
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Smith, Albert Ve ...
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Thériault, Sébas ...
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Weeke, Peter E.
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show more...
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Barnard, John
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Bis, Joshua C.
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Lyytikäinen, Leo ...
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Kleber, Marcus E
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Martinsson, Andr ...
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Lin, Henry J.
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Rienstra, Michie ...
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Trompet, Stella
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Krijthe, Bouwe P
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Dörr, Marcus
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Klarin, Derek
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Chasman, Daniel ...
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Sinner, Moritz F
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Waldenberger, Me ...
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Launer, Lenore J ...
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Harris, Tamara B
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Soliman, Elsayed ...
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Alonso, Alvaro
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Paré, Guillaume
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Teixeira, Pedro ...
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Denny, Joshua C
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Shoemaker, M. Be ...
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Van Wagoner, Dav ...
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Smith, Jonathan ...
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Psaty, Bruce M.
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Sotoodehnia, Non ...
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Taylor, Kent D
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Kähönen, Mika
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Nikus, Kjell
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Delgado, Graciel ...
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Melander, Olle
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Engström, Gunnar
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Yao, Jie
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Guo, Xiuqing
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Christophersen, ...
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Ellinor, Patrick ...
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Geelhoed, Bastia ...
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Verweij, Niek
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Macfarlane, Pete ...
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Ford, Ian
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Heeringa, Jan
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Franco, Oscar H
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Uitterlinden, An ...
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Völker, Uwe
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Teumer, Alexande ...
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Rose, Lynda M.
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Kääb, Stefan
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Gudnason, Vilmun ...
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Arking, Dan E.
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Conen, David
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Roden, Dan M
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Chung, Mina K
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Heckbert, Susan ...
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Benjamin, Emelia ...
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Lehtimäki, Terho
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März, Winfried
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Smith, Gustav
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Rotter, Jerome I ...
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van der Harst, P ...
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Jukema, J. Woute ...
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Stricker, Bruno ...
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Felix, Stephan B
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Albert, Christin ...
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Lubitz, Steven A
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Scientific Repor ...
- By the university
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Lund University